Glycoprotein nanotube traps influenza virus

Shuta Yuge, Motofusa Akiyama, Makoto Ishii, Ho Namkoong, Kazuma Yagi, Yoko Nakai, Ryo Adachi, Teruyuki Komatsu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report the synthesis, structure, and influenza A virus trapping capability of protein nanotubes with an internal wall of fetuin glycoprotein. The nanotubes were fabricated via the alternating layer-by-layer assembly of human serum albumin (HSA), poly-L-arginine (PLA), and fetuin into a track-etched polycarbonate (PC) membrane (pore size, 800 nm), followed by dissolution of the PC template. In an aqueous medium, the (PLA/HSA)5 PLA/fetuin nanotubes captured influenza A virus PR8 (H1N1) efficiently, as revealed by ELISA measurements.

Original languageEnglish
Pages (from-to)95-97
Number of pages3
JournalChemistry Letters
Volume46
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • Fetuin glycoprotein
  • Influenza virus
  • Layer-by-layer assembly

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Yuge, S., Akiyama, M., Ishii, M., Namkoong, H., Yagi, K., Nakai, Y., Adachi, R., & Komatsu, T. (2017). Glycoprotein nanotube traps influenza virus. Chemistry Letters, 46(1), 95-97. https://doi.org/10.1246/cl.160805