Glycoreplica peptides

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

“Glycoreplica peptides” are prepared using a phage display peptide library and monoclonal antibodies that recognize the carbohydrate epitopes of glycoconjugate antigens. The peptides obtained not only mimic the shapes of original glycoconjugate antigens but also have some of their functions. We herein describe how to identify the amino acid alignments of glycoreplica peptides using phage display selection against carbohydrate-binding proteins. Target-specific peptides and proteins may be selected from the large repertory of a peptide/protein library using phage display technology. Glycoreplica peptides have the potential to become alternatives to carbohydrate ligands such as mimotopes for vaccinations and carbohydrate-derived drugs for carbohydrate-related diseases.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages437-447
Number of pages11
DOIs
Publication statusPublished - 2018 Jan 1

Publication series

NameMethods in Molecular Biology
Volume1804
ISSN (Print)1064-3745

Keywords

  • Anti-carbohydrate antibody
  • Glycosidase inhibitor
  • Lectin
  • Phage display technology
  • Random peptide library

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'Glycoreplica peptides'. Together they form a unique fingerprint.

  • Cite this

    Matsubara, T., Sato, T., & Taki, T. (2018). Glycoreplica peptides. In Methods in Molecular Biology (pp. 437-447). (Methods in Molecular Biology; Vol. 1804). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8552-4_23