Glycosidase inhibition by plant alkaloids which are structural analogues of monosaccharides

S. V. Evans, L. E. Fellows, T. K.M. Shing, G. W.J. Fleet

Research output: Contribution to journalArticlepeer-review

189 Citations (Scopus)

Abstract

]The inhibitory activities of three plant alkaloids, deoxynojirimycin, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine and 1,5 dideoxy-1,5-imino-D-mannitol towards glycosidases from several sources have been compared. These are structural analogues of D-glucose, D-fructose and D-mannose respectively. The occurrence of 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine in Lonchocarpus sericeus seed is confirmed and has been shown to be responsible for the glucosidase inhibition wrongly attributed to 1,5-dideoxy-1,5-imino-D-mannitol in a previous report.

Original languageEnglish
Pages (from-to)1953-1955
Number of pages3
JournalPhytochemistry
Volume24
Issue number9
DOIs
Publication statusPublished - 1985

Keywords

  • -Glycosidase
  • 1,5-dideoxy-1,5-imino-D-mannitol.
  • 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine
  • alkaloids
  • deoxynojirimycin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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