Golden mean to longevity: Rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease

Masashi Tanaka, Noriyuki Fuku, Takeshi Takeyasu, Li Jun Guo, Raita Hirose, Miyuki Kurata, Harm Jan W. Borgeld, Yoshiji Yamada, Wakako Maruyama, Yasumichi Arai, Nobuyoshi Hirose, Yoshiharu Oshida, Yuzo Sato, Nobutaka Hattori, Yoshikuni Mizuno, So Iwata, Kunio Yagi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To test the hypothesis that centenarians are free from deleterious mitochondrial variations, we analyzed amino acid variations in the cytochrome b molecule of 64 Japanese centenarians. Although the frequencies of some variations, such as N260D and G251S, differed significantly between centenarians and patients with Parkinson's disease, the most striking feature of centenarian cytochrome b was the rareness of amino acid variations in contrast to the variety of amino acid replacements in patients with Parkinson's disease. These results suggest that centenarians are genetically hitting the "golden mean" (less variation from the consensus cytochrome b sequence or less mismatch with other subunits). A multiplex detection system for various deleterious variations in combination with genetic tests for longevity-associated genotypes will be necessary to predict longevity or age-related diseases.

Original languageEnglish
Pages (from-to)347-355
Number of pages9
JournalJournal of neuroscience research
Volume70
Issue number3
DOIs
Publication statusPublished - 2002 Nov 2

Keywords

  • Amino acid variation
  • Mitochondrial DNA
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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    Tanaka, M., Fuku, N., Takeyasu, T., Guo, L. J., Hirose, R., Kurata, M., Borgeld, H. J. W., Yamada, Y., Maruyama, W., Arai, Y., Hirose, N., Oshida, Y., Sato, Y., Hattori, N., Mizuno, Y., Iwata, S., & Yagi, K. (2002). Golden mean to longevity: Rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease. Journal of neuroscience research, 70(3), 347-355. https://doi.org/10.1002/jnr.10444