Gonadoblastoma, mixed germ cell tumor, and Y chromosomal genotype: Molecular analysis in four patients

Koji Muroya, Tomohiro Ishii, Yutaka Nakahori, Yumi Asakura, Katsuhiko Tachibana, Mitsuo Masuno, Kiyoshi Imaizumi, Yukichi Tanaka, Yasusada Kawada, Shigenori Yukizane, Tsutomu Ogata

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

This study reports on Y chromosomal genotypes of three patients with gonadoblastoma and one patient with gonadoblastoma and mixed germ cell tumor. Molecular analysis for 35 Y chromosomal loci was performed for DNA samples taken from peripheral leukocytes and lymphoblastoid cell lines, showing that the four patients shared the region between DYS267 at interval 4A and DYF50S1 at interval 6D, with the exception of the region around DYS202 at interval 5K. In the patient with gonadoblastoma and mixed germ cell tumor, Y chromosomal material was preserved in the gonadoblastoma but was lost from the mixed germ cell tumor. The results, in conjunction with previous reports, suggest that GBY (gonadoblastoma locus on the Y chromosome) may be located to a roughly 5-Mb pericentromeric region between DYS267 at interval 4A and DYS270 at interval 5A. The presence of Y chromosomal material in gonadoblastoma is consistent with GBY being involved in the development of gonadoblastoma, and the absence of Y chromosomal material in mixed germ cell tumor would be explained as a consequence of Y chromosomal loss from rapidly proliferating gonadal cancer cells.

Original languageEnglish
Pages (from-to)40-45
Number of pages6
JournalGenes Chromosomes and Cancer
Volume25
Issue number1
DOIs
Publication statusPublished - 1999 May 1

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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