Grading criteria for chronic ocular graft-versus-host disease

Comparing the NIH eye score, Japanese dry eye score, and DEWS 2007 score

Yukako Tatematsu, Yoko Ogawa, Takayuki Abe, Mizuka Kamoi, Miki Uchino, Yumiko Saijo-Ban, Saori Yaguchi, Shin Mukai, Takehiko Mori, Shinichiro Okamoto, Kazuo Tsubota

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Abstract

Ocular graft-versus-host disease (GVHD) is a common complication after hematopoietic stem cell transplantation (HSCT). Here we compared the diagnostic rates of ocular GVHD, including its severity, prognosis and the agreement, obtained using three grading scales: the National Institutes of Health (NIH) eye score, Japanese dry eye score, and dry eye workshop score, by retrospectively reviewing the records of 82 patients who underwent HSCT. Tear dynamics and ocular surface assessments made 6-9 months after HSCT were used to determine ocular GVHD severity with the three scales. By the three scales, ocular GVHD was diagnosed in 56 patients (68.3%), 51 patients (62.2%), and 52 patients (63.4%), respectively. The Kappa coefficient was calculated to determine the agreement between scales for diagnosing ocular GVHD. The severity progression within two years after onset was also assessed by tear dynamics and ocular surface examination. The patients were categorized as no change, improved, or progressive. The three grading scales showed good agreement (Kappa 50.87 to 0.97) indiagnosing patients with ocular GVHD, and the scores by all three were significantly associated with the patients' prognosis (p <0.01). We recommend that multi-center research is needed for further validation and investigation.

Original languageEnglish
Article number6680
JournalScientific Reports
Volume4
DOIs
Publication statusPublished - 2014 Oct 22

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National Institutes of Health (U.S.)
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Tears
Education

ASJC Scopus subject areas

  • General
  • Medicine(all)

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Grading criteria for chronic ocular graft-versus-host disease : Comparing the NIH eye score, Japanese dry eye score, and DEWS 2007 score. / Tatematsu, Yukako; Ogawa, Yoko; Abe, Takayuki; Kamoi, Mizuka; Uchino, Miki; Saijo-Ban, Yumiko; Yaguchi, Saori; Mukai, Shin; Mori, Takehiko; Okamoto, Shinichiro; Tsubota, Kazuo.

In: Scientific Reports, Vol. 4, 6680, 22.10.2014.

Research output: Contribution to journalArticle

Tatematsu, Yukako ; Ogawa, Yoko ; Abe, Takayuki ; Kamoi, Mizuka ; Uchino, Miki ; Saijo-Ban, Yumiko ; Yaguchi, Saori ; Mukai, Shin ; Mori, Takehiko ; Okamoto, Shinichiro ; Tsubota, Kazuo. / Grading criteria for chronic ocular graft-versus-host disease : Comparing the NIH eye score, Japanese dry eye score, and DEWS 2007 score. In: Scientific Reports. 2014 ; Vol. 4.
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