Gradual vs. wait-and-gradual discontinuation in antipsychotic switching: A meta-analysis

Hiroyoshi Takeuchi, Sadhana Thiyanavadivel, Ofer Agid, Gary Remington

Research output: Contribution to journalArticle

4 Citations (Scopus)


To address whether wait discontinuation (i.e., introducing the new antipsychotic while maintaining the first for a period before initiating its discontinuation) is superior to non-wait discontinuation (i.e., initiating the first antipsychotic's discontinuation when introducing the new antipsychotic) in antipsychotic switching, we conducted a meta-analysis of randomized controlled trials comparing gradual vs. wait-and-gradual antipsychotic discontinuation in patients with schizophrenia. The meta-analysis of 5 studies (n = 410) demonstrated no significant differences in any clinical outcomes, including study discontinuation, psychopathology, extrapyramidal symptoms, and treatment-emergent adverse events, between the two groups. These findings indicate either strategy can be used in clinical practice.

Original languageEnglish
JournalSchizophrenia Research
Publication statusAccepted/In press - 2016 Dec 29


  • Antipsychotics
  • Discontinuation
  • Schizophrenia
  • Switching strategy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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