Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury

Soya Kawabata, Morito Takano, Yuko Numasawa-Kuroiwa, Go Itakura, Yoshiomi Kobayashi, Yuichiro Nishiyama, Keiko Sugai, Soraya Nishimura, Hiroki Iwai, Miho Isoda, Shinsuke Shibata, Jun Kohyama, Akio Iwanami, Yoshiaki Toyama, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regeneration of the injured spinal cord, human iPSC-NS/PCs predominantly differentiate into neurons both in vitro and in vivo. We therefore took advantage of our recently developed protocol to obtain human-induced pluripotent stem cell-derived oligodendrocyte precursor cell-enriched neural stem/progenitor cells and report the benefits of transplanting these cells in a spinal cord injury (SCI) model. We describe how this approach contributes to the robust remyelination of demyelinated axons and facilitates functional recovery after SCI.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalStem Cell Reports
Volume6
Issue number1
DOIs
Publication statusPublished - 2016 Jan 12

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Developmental Biology
  • Genetics

Fingerprint Dive into the research topics of 'Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury'. Together they form a unique fingerprint.

Cite this