Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury

Soya Kawabata, Morito Takano, Yuko Numasawa-Kuroiwa, Go Itakura, Yoshiomi Kobayashi, Yuichiro Nishiyama, Keiko Sugai, Soraya Nishimura, Hiroki Iwai, Miho Isoda, Shinsuke Shibata, Jun Kohyama, Akio Iwanami, Yoshiaki Toyama, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regeneration of the injured spinal cord, human iPSC-NS/PCs predominantly differentiate into neurons both in vitro and in vivo. We therefore took advantage of our recently developed protocol to obtain human-induced pluripotent stem cell-derived oligodendrocyte precursor cell-enriched neural stem/progenitor cells and report the benefits of transplanting these cells in a spinal cord injury (SCI) model. We describe how this approach contributes to the robust remyelination of demyelinated axons and facilitates functional recovery after SCI.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalStem Cell Reports
Volume6
Issue number1
DOIs
Publication statusPublished - 2016 Jan 12

Fingerprint

Induced Pluripotent Stem Cells
Neural Stem Cells
Oligodendroglia
Stem cells
Spinal Cord Injuries
Axons
Stem Cells
Spinal Cord Regeneration
Primates
Rodentia
Spinal Cord
Transplantation
Neurons
Recovery

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Developmental Biology
  • Genetics

Cite this

Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury. / Kawabata, Soya; Takano, Morito; Numasawa-Kuroiwa, Yuko; Itakura, Go; Kobayashi, Yoshiomi; Nishiyama, Yuichiro; Sugai, Keiko; Nishimura, Soraya; Iwai, Hiroki; Isoda, Miho; Shibata, Shinsuke; Kohyama, Jun; Iwanami, Akio; Toyama, Yoshiaki; Matsumoto, Morio; Nakamura, Masaya; Okano, Hideyuki.

In: Stem Cell Reports, Vol. 6, No. 1, 12.01.2016, p. 1-8.

Research output: Contribution to journalArticle

Kawabata, S, Takano, M, Numasawa-Kuroiwa, Y, Itakura, G, Kobayashi, Y, Nishiyama, Y, Sugai, K, Nishimura, S, Iwai, H, Isoda, M, Shibata, S, Kohyama, J, Iwanami, A, Toyama, Y, Matsumoto, M, Nakamura, M & Okano, H 2016, 'Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury', Stem Cell Reports, vol. 6, no. 1, pp. 1-8. https://doi.org/10.1016/j.stemcr.2015.11.013
Kawabata, Soya ; Takano, Morito ; Numasawa-Kuroiwa, Yuko ; Itakura, Go ; Kobayashi, Yoshiomi ; Nishiyama, Yuichiro ; Sugai, Keiko ; Nishimura, Soraya ; Iwai, Hiroki ; Isoda, Miho ; Shibata, Shinsuke ; Kohyama, Jun ; Iwanami, Akio ; Toyama, Yoshiaki ; Matsumoto, Morio ; Nakamura, Masaya ; Okano, Hideyuki. / Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury. In: Stem Cell Reports. 2016 ; Vol. 6, No. 1. pp. 1-8.
@article{cb8b086b99c341a3a5206d7db36f758c,
title = "Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury",
abstract = "Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regeneration of the injured spinal cord, human iPSC-NS/PCs predominantly differentiate into neurons both in vitro and in vivo. We therefore took advantage of our recently developed protocol to obtain human-induced pluripotent stem cell-derived oligodendrocyte precursor cell-enriched neural stem/progenitor cells and report the benefits of transplanting these cells in a spinal cord injury (SCI) model. We describe how this approach contributes to the robust remyelination of demyelinated axons and facilitates functional recovery after SCI.",
author = "Soya Kawabata and Morito Takano and Yuko Numasawa-Kuroiwa and Go Itakura and Yoshiomi Kobayashi and Yuichiro Nishiyama and Keiko Sugai and Soraya Nishimura and Hiroki Iwai and Miho Isoda and Shinsuke Shibata and Jun Kohyama and Akio Iwanami and Yoshiaki Toyama and Morio Matsumoto and Masaya Nakamura and Hideyuki Okano",
year = "2016",
month = "1",
day = "12",
doi = "10.1016/j.stemcr.2015.11.013",
language = "English",
volume = "6",
pages = "1--8",
journal = "Stem Cell Reports",
issn = "2213-6711",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury

AU - Kawabata, Soya

AU - Takano, Morito

AU - Numasawa-Kuroiwa, Yuko

AU - Itakura, Go

AU - Kobayashi, Yoshiomi

AU - Nishiyama, Yuichiro

AU - Sugai, Keiko

AU - Nishimura, Soraya

AU - Iwai, Hiroki

AU - Isoda, Miho

AU - Shibata, Shinsuke

AU - Kohyama, Jun

AU - Iwanami, Akio

AU - Toyama, Yoshiaki

AU - Matsumoto, Morio

AU - Nakamura, Masaya

AU - Okano, Hideyuki

PY - 2016/1/12

Y1 - 2016/1/12

N2 - Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regeneration of the injured spinal cord, human iPSC-NS/PCs predominantly differentiate into neurons both in vitro and in vivo. We therefore took advantage of our recently developed protocol to obtain human-induced pluripotent stem cell-derived oligodendrocyte precursor cell-enriched neural stem/progenitor cells and report the benefits of transplanting these cells in a spinal cord injury (SCI) model. We describe how this approach contributes to the robust remyelination of demyelinated axons and facilitates functional recovery after SCI.

AB - Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regeneration of the injured spinal cord, human iPSC-NS/PCs predominantly differentiate into neurons both in vitro and in vivo. We therefore took advantage of our recently developed protocol to obtain human-induced pluripotent stem cell-derived oligodendrocyte precursor cell-enriched neural stem/progenitor cells and report the benefits of transplanting these cells in a spinal cord injury (SCI) model. We describe how this approach contributes to the robust remyelination of demyelinated axons and facilitates functional recovery after SCI.

UR - http://www.scopus.com/inward/record.url?scp=84955358038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955358038&partnerID=8YFLogxK

U2 - 10.1016/j.stemcr.2015.11.013

DO - 10.1016/j.stemcr.2015.11.013

M3 - Article

C2 - 26724902

AN - SCOPUS:84955358038

VL - 6

SP - 1

EP - 8

JO - Stem Cell Reports

JF - Stem Cell Reports

SN - 2213-6711

IS - 1

ER -