Granular lymphocytic leukemia derived from γδ T-cell expressing cytotoxic molecules

Takeshi Saito, Kazuto Togitani, Jun Murakami, Takashi Watanabe, Ryuji Tanosaki, Yukio Kobayashi, Yoshihiro Matsuno, Kensei Tobinai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We here present an extremely rare case of granular lymphocytic leukemia derived from γδ T-cell (γδ T-GLL). The blood picture at diagnosis was as follows; white cell count 25.7×109/l containing 94% atypical lymphocytes with cytoplasmic granules, hemoglobin 11.8 g/dl and platelet count 124×109/l. The atypical lymphocytes were positive for CD2, CD3, CD5, CD7, CD56 and TCR γδ, but negative for CD4, CD8, CD57, TCR αβ and B-cell antigens. The cytotoxic molecules, T-cell intracellular antigen-1 (TIA-1) and granzyme B, were positive by immunocytochemical analysis. Southern blot analysis showed rearrangement of T-cell receptor Jγ and Cβ genes but germline configuration of the JH gene. Neither serum antibody against human T-cell leukemia virus type-I (HTLV-I) nor the integration of HTLV-I proviral DNA was detected. CT scan showed splenomegaly but no lymph node enlargement. A diagnosis of γδ T-GLL was made, and she has been followed up without any therapies for more than 4 years.

Original languageEnglish
Pages (from-to)259-261
Number of pages3
JournalLeukemia Research
Volume25
Issue number3
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

T-Cell Leukemia
HTLV-I Antibodies
Lymphocytes
Cytoplasmic Granules
Antigens
Granzymes
Human T-lymphotropic virus 1
Splenomegaly
T-Cell Antigen Receptor
Southern Blotting
Platelet Count
Genes
Hemoglobins
B-Lymphocytes
Cell Count
Lymph Nodes
T-Lymphocytes
DNA
Serum
Therapeutics

Keywords

  • γδ T-cell
  • γδ T-GLL
  • Cytotoxic molecule
  • Granular lymphocytic leukemia
  • T-cell receptor

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Saito, T., Togitani, K., Murakami, J., Watanabe, T., Tanosaki, R., Kobayashi, Y., ... Tobinai, K. (2001). Granular lymphocytic leukemia derived from γδ T-cell expressing cytotoxic molecules. Leukemia Research, 25(3), 259-261. https://doi.org/10.1016/S0145-2126(00)00115-6

Granular lymphocytic leukemia derived from γδ T-cell expressing cytotoxic molecules. / Saito, Takeshi; Togitani, Kazuto; Murakami, Jun; Watanabe, Takashi; Tanosaki, Ryuji; Kobayashi, Yukio; Matsuno, Yoshihiro; Tobinai, Kensei.

In: Leukemia Research, Vol. 25, No. 3, 2001, p. 259-261.

Research output: Contribution to journalArticle

Saito, T, Togitani, K, Murakami, J, Watanabe, T, Tanosaki, R, Kobayashi, Y, Matsuno, Y & Tobinai, K 2001, 'Granular lymphocytic leukemia derived from γδ T-cell expressing cytotoxic molecules', Leukemia Research, vol. 25, no. 3, pp. 259-261. https://doi.org/10.1016/S0145-2126(00)00115-6
Saito, Takeshi ; Togitani, Kazuto ; Murakami, Jun ; Watanabe, Takashi ; Tanosaki, Ryuji ; Kobayashi, Yukio ; Matsuno, Yoshihiro ; Tobinai, Kensei. / Granular lymphocytic leukemia derived from γδ T-cell expressing cytotoxic molecules. In: Leukemia Research. 2001 ; Vol. 25, No. 3. pp. 259-261.
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