Granular lymphocytic leukemia derived from γδ T-cell expressing cytotoxic molecules

Takeshi Saito, Kazuto Togitani, Jun Murakami, Takashi Watanabe, Ryuji Tanosaki, Yukio Kobayashi, Yoshihiro Matsuno, Kensei Tobinai

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Abstract

We here present an extremely rare case of granular lymphocytic leukemia derived from γδ T-cell (γδ T-GLL). The blood picture at diagnosis was as follows; white cell count 25.7×109/l containing 94% atypical lymphocytes with cytoplasmic granules, hemoglobin 11.8 g/dl and platelet count 124×109/l. The atypical lymphocytes were positive for CD2, CD3, CD5, CD7, CD56 and TCR γδ, but negative for CD4, CD8, CD57, TCR αβ and B-cell antigens. The cytotoxic molecules, T-cell intracellular antigen-1 (TIA-1) and granzyme B, were positive by immunocytochemical analysis. Southern blot analysis showed rearrangement of T-cell receptor Jγ and Cβ genes but germline configuration of the JH gene. Neither serum antibody against human T-cell leukemia virus type-I (HTLV-I) nor the integration of HTLV-I proviral DNA was detected. CT scan showed splenomegaly but no lymph node enlargement. A diagnosis of γδ T-GLL was made, and she has been followed up without any therapies for more than 4 years.

Original languageEnglish
Pages (from-to)259-261
Number of pages3
JournalLeukemia Research
Volume25
Issue number3
DOIs
Publication statusPublished - 2001 Feb 27

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Keywords

  • Cytotoxic molecule
  • Granular lymphocytic leukemia
  • T-cell receptor
  • γδ T-GLL
  • γδ T-cell

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Saito, T., Togitani, K., Murakami, J., Watanabe, T., Tanosaki, R., Kobayashi, Y., Matsuno, Y., & Tobinai, K. (2001). Granular lymphocytic leukemia derived from γδ T-cell expressing cytotoxic molecules. Leukemia Research, 25(3), 259-261. https://doi.org/10.1016/S0145-2126(00)00115-6