Granulocyte Colony-stimulating Factor-producing Upper Urinary Tract Carcinoma: Systematic Review of 46 Cases Reported in Japan

Kazuhiro Matsumoto, N. Hayakawa, S. Nakamura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: Granulocyte colony-stimulating factor (G-CSF)-producing upper urinary tract carcinoma is extremely rare, and we do not yet have a comprehensive understanding of the disease. This study was carried out to determine the characteristics of G-CSF-producing upper urinary tract carcinoma. Materials and methods: A systematic MEDLINE and ICHUSHI WEB (Japan Medical Abstract Society) search was carried out to identify articles and conference proceedings describing patients with G-CSF-producing upper urinary tract carcinoma. The final cohort included 46 patients: eight studies were published in English, 16 in Japanese and there were 18 Japanese conference proceedings. Results: The average age of patients was 67 years and the male to female ratio was 2.5 to 1. The mean white blood cell count was as high as 33 900/μl (range 10 000-121 000) in these patients. Pretreatment serum G-CSF levels were measured in 23 patients, all of which were higher (range 55-1220pg/ml) than normal levels. Metastasis was detected in 29 patients (63%) and lymph node and lung metastases were well observed. The most commonly reported primary treatment was surgery (33 patients), but the median survival period for these patients was short (4.5 months). Multivariate analysis showed that lymph node and/or distant metastasis (hazard ratio 2.92, P=0.020) and the absence of adjuvant therapy (hazard ratio 3.20, P=0.014) were independent risk factors for mortality. A total of only seven patients survived more than 1 year and most had a history of neoadjuvant/adjuvant chemotherapy and/or radiation therapy. Conclusion: We believe that the presence of G-CSF-induced leukocytosis represents a distinct and highly aggressive form of upper urinary tract carcinoma. However, the results of our systematic review indicate that a multidisciplinary approach including surgery, neoadjuvant or adjuvant chemotherapy and radiotherapy may have the potential to control the disease, although we cannot provide definitive recommendations from this retrospective study.

Original languageEnglish
Pages (from-to)781-788
Number of pages8
JournalClinical Oncology
Volume26
Issue number12
DOIs
Publication statusPublished - 2014 Dec 1
Externally publishedYes

Fingerprint

Granulocyte Colony-Stimulating Factor
Urinary Tract
Japan
Carcinoma
Adjuvant Chemotherapy
Neoplasm Metastasis
Lymph Nodes
Adjuvant Radiotherapy
Medical Societies
Leukocytosis
Leukocyte Count
MEDLINE
Radiotherapy
Multivariate Analysis
Retrospective Studies
Lung
Survival
Mortality
Therapeutics
Serum

Keywords

  • G-CSF
  • Granulocyte colony-stimulating factor
  • Renal pelvis
  • Upper urinary tract carcinoma
  • Ureter

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Granulocyte Colony-stimulating Factor-producing Upper Urinary Tract Carcinoma : Systematic Review of 46 Cases Reported in Japan. / Matsumoto, Kazuhiro; Hayakawa, N.; Nakamura, S.

In: Clinical Oncology, Vol. 26, No. 12, 01.12.2014, p. 781-788.

Research output: Contribution to journalArticle

@article{249c79e8b2474cef9a837c3746e569dd,
title = "Granulocyte Colony-stimulating Factor-producing Upper Urinary Tract Carcinoma: Systematic Review of 46 Cases Reported in Japan",
abstract = "Aims: Granulocyte colony-stimulating factor (G-CSF)-producing upper urinary tract carcinoma is extremely rare, and we do not yet have a comprehensive understanding of the disease. This study was carried out to determine the characteristics of G-CSF-producing upper urinary tract carcinoma. Materials and methods: A systematic MEDLINE and ICHUSHI WEB (Japan Medical Abstract Society) search was carried out to identify articles and conference proceedings describing patients with G-CSF-producing upper urinary tract carcinoma. The final cohort included 46 patients: eight studies were published in English, 16 in Japanese and there were 18 Japanese conference proceedings. Results: The average age of patients was 67 years and the male to female ratio was 2.5 to 1. The mean white blood cell count was as high as 33 900/μl (range 10 000-121 000) in these patients. Pretreatment serum G-CSF levels were measured in 23 patients, all of which were higher (range 55-1220pg/ml) than normal levels. Metastasis was detected in 29 patients (63{\%}) and lymph node and lung metastases were well observed. The most commonly reported primary treatment was surgery (33 patients), but the median survival period for these patients was short (4.5 months). Multivariate analysis showed that lymph node and/or distant metastasis (hazard ratio 2.92, P=0.020) and the absence of adjuvant therapy (hazard ratio 3.20, P=0.014) were independent risk factors for mortality. A total of only seven patients survived more than 1 year and most had a history of neoadjuvant/adjuvant chemotherapy and/or radiation therapy. Conclusion: We believe that the presence of G-CSF-induced leukocytosis represents a distinct and highly aggressive form of upper urinary tract carcinoma. However, the results of our systematic review indicate that a multidisciplinary approach including surgery, neoadjuvant or adjuvant chemotherapy and radiotherapy may have the potential to control the disease, although we cannot provide definitive recommendations from this retrospective study.",
keywords = "G-CSF, Granulocyte colony-stimulating factor, Renal pelvis, Upper urinary tract carcinoma, Ureter",
author = "Kazuhiro Matsumoto and N. Hayakawa and S. Nakamura",
year = "2014",
month = "12",
day = "1",
doi = "10.1016/j.clon.2014.08.006",
language = "English",
volume = "26",
pages = "781--788",
journal = "Clinical Oncology",
issn = "0936-6555",
publisher = "W.B. Saunders Ltd",
number = "12",

}

TY - JOUR

T1 - Granulocyte Colony-stimulating Factor-producing Upper Urinary Tract Carcinoma

T2 - Systematic Review of 46 Cases Reported in Japan

AU - Matsumoto, Kazuhiro

AU - Hayakawa, N.

AU - Nakamura, S.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Aims: Granulocyte colony-stimulating factor (G-CSF)-producing upper urinary tract carcinoma is extremely rare, and we do not yet have a comprehensive understanding of the disease. This study was carried out to determine the characteristics of G-CSF-producing upper urinary tract carcinoma. Materials and methods: A systematic MEDLINE and ICHUSHI WEB (Japan Medical Abstract Society) search was carried out to identify articles and conference proceedings describing patients with G-CSF-producing upper urinary tract carcinoma. The final cohort included 46 patients: eight studies were published in English, 16 in Japanese and there were 18 Japanese conference proceedings. Results: The average age of patients was 67 years and the male to female ratio was 2.5 to 1. The mean white blood cell count was as high as 33 900/μl (range 10 000-121 000) in these patients. Pretreatment serum G-CSF levels were measured in 23 patients, all of which were higher (range 55-1220pg/ml) than normal levels. Metastasis was detected in 29 patients (63%) and lymph node and lung metastases were well observed. The most commonly reported primary treatment was surgery (33 patients), but the median survival period for these patients was short (4.5 months). Multivariate analysis showed that lymph node and/or distant metastasis (hazard ratio 2.92, P=0.020) and the absence of adjuvant therapy (hazard ratio 3.20, P=0.014) were independent risk factors for mortality. A total of only seven patients survived more than 1 year and most had a history of neoadjuvant/adjuvant chemotherapy and/or radiation therapy. Conclusion: We believe that the presence of G-CSF-induced leukocytosis represents a distinct and highly aggressive form of upper urinary tract carcinoma. However, the results of our systematic review indicate that a multidisciplinary approach including surgery, neoadjuvant or adjuvant chemotherapy and radiotherapy may have the potential to control the disease, although we cannot provide definitive recommendations from this retrospective study.

AB - Aims: Granulocyte colony-stimulating factor (G-CSF)-producing upper urinary tract carcinoma is extremely rare, and we do not yet have a comprehensive understanding of the disease. This study was carried out to determine the characteristics of G-CSF-producing upper urinary tract carcinoma. Materials and methods: A systematic MEDLINE and ICHUSHI WEB (Japan Medical Abstract Society) search was carried out to identify articles and conference proceedings describing patients with G-CSF-producing upper urinary tract carcinoma. The final cohort included 46 patients: eight studies were published in English, 16 in Japanese and there were 18 Japanese conference proceedings. Results: The average age of patients was 67 years and the male to female ratio was 2.5 to 1. The mean white blood cell count was as high as 33 900/μl (range 10 000-121 000) in these patients. Pretreatment serum G-CSF levels were measured in 23 patients, all of which were higher (range 55-1220pg/ml) than normal levels. Metastasis was detected in 29 patients (63%) and lymph node and lung metastases were well observed. The most commonly reported primary treatment was surgery (33 patients), but the median survival period for these patients was short (4.5 months). Multivariate analysis showed that lymph node and/or distant metastasis (hazard ratio 2.92, P=0.020) and the absence of adjuvant therapy (hazard ratio 3.20, P=0.014) were independent risk factors for mortality. A total of only seven patients survived more than 1 year and most had a history of neoadjuvant/adjuvant chemotherapy and/or radiation therapy. Conclusion: We believe that the presence of G-CSF-induced leukocytosis represents a distinct and highly aggressive form of upper urinary tract carcinoma. However, the results of our systematic review indicate that a multidisciplinary approach including surgery, neoadjuvant or adjuvant chemotherapy and radiotherapy may have the potential to control the disease, although we cannot provide definitive recommendations from this retrospective study.

KW - G-CSF

KW - Granulocyte colony-stimulating factor

KW - Renal pelvis

KW - Upper urinary tract carcinoma

KW - Ureter

UR - http://www.scopus.com/inward/record.url?scp=84911463503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911463503&partnerID=8YFLogxK

U2 - 10.1016/j.clon.2014.08.006

DO - 10.1016/j.clon.2014.08.006

M3 - Article

C2 - 25179323

AN - SCOPUS:84911463503

VL - 26

SP - 781

EP - 788

JO - Clinical Oncology

JF - Clinical Oncology

SN - 0936-6555

IS - 12

ER -