Granuloma caused by subcutaneous injection of leuprorelin acetate product: Case report and histopathological findings

Takeshi Ouchi, Tetushi Koyama, Naho Miyata, Makoto Sugiura

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Leuprorelin acetate is a luteinizing hormone-releasing hormone (LH-RH) analog, which is used for chemical castration. Chemical castration treatment has an especially important role for prostate cancer. To ensure ongoing chemical castration, a novel sustained-action injection system using spherical microcapsules has been developed. We report a patient who had granuloma caused by administration of the 11.25 mg leuprorelin acetate product. Histological examination revealed many giant cells with vacuoles. On the basis of reported cases, these vacuoles are characteristic for the granuloma caused by leuprorelin acetate product. The vacuoles in the granuloma are the same size as the microcapsules, and their shape is almost spherical. We assume that the vacuoles in the granuloma are actually the microcapsules. We expect that there will be investigations regarding the procatarctic cause of granuloma formation.

Original languageEnglish
Pages (from-to)719-721
Number of pages3
JournalJournal of Dermatology
Volume33
Issue number10
DOIs
Publication statusPublished - 2006 Oct
Externally publishedYes

Fingerprint

Leuprolide
Subcutaneous Injections
Granuloma
Vacuoles
Acetates
Castration
Capsules
Giant Cells
Gonadotropin-Releasing Hormone
Prostatic Neoplasms
Injections

Keywords

  • Granuloma
  • Lactic acid
  • Leuprorelin
  • Subcutaneous injection
  • Vacuoles

ASJC Scopus subject areas

  • Dermatology

Cite this

Granuloma caused by subcutaneous injection of leuprorelin acetate product : Case report and histopathological findings. / Ouchi, Takeshi; Koyama, Tetushi; Miyata, Naho; Sugiura, Makoto.

In: Journal of Dermatology, Vol. 33, No. 10, 10.2006, p. 719-721.

Research output: Contribution to journalArticle

@article{5b1e4bc25a344ebaa11f631fca202d35,
title = "Granuloma caused by subcutaneous injection of leuprorelin acetate product: Case report and histopathological findings",
abstract = "Leuprorelin acetate is a luteinizing hormone-releasing hormone (LH-RH) analog, which is used for chemical castration. Chemical castration treatment has an especially important role for prostate cancer. To ensure ongoing chemical castration, a novel sustained-action injection system using spherical microcapsules has been developed. We report a patient who had granuloma caused by administration of the 11.25 mg leuprorelin acetate product. Histological examination revealed many giant cells with vacuoles. On the basis of reported cases, these vacuoles are characteristic for the granuloma caused by leuprorelin acetate product. The vacuoles in the granuloma are the same size as the microcapsules, and their shape is almost spherical. We assume that the vacuoles in the granuloma are actually the microcapsules. We expect that there will be investigations regarding the procatarctic cause of granuloma formation.",
keywords = "Granuloma, Lactic acid, Leuprorelin, Subcutaneous injection, Vacuoles",
author = "Takeshi Ouchi and Tetushi Koyama and Naho Miyata and Makoto Sugiura",
year = "2006",
month = "10",
doi = "10.1111/j.1346-8138.2006.00167.x",
language = "English",
volume = "33",
pages = "719--721",
journal = "Journal of Dermatology",
issn = "0385-2407",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Granuloma caused by subcutaneous injection of leuprorelin acetate product

T2 - Case report and histopathological findings

AU - Ouchi, Takeshi

AU - Koyama, Tetushi

AU - Miyata, Naho

AU - Sugiura, Makoto

PY - 2006/10

Y1 - 2006/10

N2 - Leuprorelin acetate is a luteinizing hormone-releasing hormone (LH-RH) analog, which is used for chemical castration. Chemical castration treatment has an especially important role for prostate cancer. To ensure ongoing chemical castration, a novel sustained-action injection system using spherical microcapsules has been developed. We report a patient who had granuloma caused by administration of the 11.25 mg leuprorelin acetate product. Histological examination revealed many giant cells with vacuoles. On the basis of reported cases, these vacuoles are characteristic for the granuloma caused by leuprorelin acetate product. The vacuoles in the granuloma are the same size as the microcapsules, and their shape is almost spherical. We assume that the vacuoles in the granuloma are actually the microcapsules. We expect that there will be investigations regarding the procatarctic cause of granuloma formation.

AB - Leuprorelin acetate is a luteinizing hormone-releasing hormone (LH-RH) analog, which is used for chemical castration. Chemical castration treatment has an especially important role for prostate cancer. To ensure ongoing chemical castration, a novel sustained-action injection system using spherical microcapsules has been developed. We report a patient who had granuloma caused by administration of the 11.25 mg leuprorelin acetate product. Histological examination revealed many giant cells with vacuoles. On the basis of reported cases, these vacuoles are characteristic for the granuloma caused by leuprorelin acetate product. The vacuoles in the granuloma are the same size as the microcapsules, and their shape is almost spherical. We assume that the vacuoles in the granuloma are actually the microcapsules. We expect that there will be investigations regarding the procatarctic cause of granuloma formation.

KW - Granuloma

KW - Lactic acid

KW - Leuprorelin

KW - Subcutaneous injection

KW - Vacuoles

UR - http://www.scopus.com/inward/record.url?scp=33749578090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749578090&partnerID=8YFLogxK

U2 - 10.1111/j.1346-8138.2006.00167.x

DO - 10.1111/j.1346-8138.2006.00167.x

M3 - Article

C2 - 17040504

AN - SCOPUS:33749578090

VL - 33

SP - 719

EP - 721

JO - Journal of Dermatology

JF - Journal of Dermatology

SN - 0385-2407

IS - 10

ER -