Graphical and analytic criteria for the existence of protein level oscillations in cyclic gene regulatory networks

Yutaka Hori, Tae Hyoung Kim, Shinji Hara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

This paper investigates the criteria for the existence of protein level oscillations in a class of gene regulatory networks, where a nonlinear differential equation model is considered to analyze its dynamical behavior. There are two steps to derive such criteria: We first employ a Poincaŕe-Bendixson type theorem to restrict the class of solution trajectories, and then carry out a local stability analysis of linearized systems with a generalized frequency variable. Then, our main results, graphical and its equivalent analytic criteria which are easily applicable for the networks consisting of arbitrary number of genes, are derived. Their distinctive features are also verified through numerical simulations.

Original languageEnglish
Title of host publicationProceedings of the 48th IEEE Conference on Decision and Control held jointly with 2009 28th Chinese Control Conference, CDC/CCC 2009
Pages3521-3526
Number of pages6
DOIs
Publication statusPublished - 2009 Dec 1
Externally publishedYes
Event48th IEEE Conference on Decision and Control held jointly with 2009 28th Chinese Control Conference, CDC/CCC 2009 - Shanghai, China
Duration: 2009 Dec 152009 Dec 18

Publication series

NameProceedings of the IEEE Conference on Decision and Control
ISSN (Print)0191-2216

Other

Other48th IEEE Conference on Decision and Control held jointly with 2009 28th Chinese Control Conference, CDC/CCC 2009
CountryChina
CityShanghai
Period09/12/1509/12/18

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Modelling and Simulation
  • Control and Optimization

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  • Cite this

    Hori, Y., Kim, T. H., & Hara, S. (2009). Graphical and analytic criteria for the existence of protein level oscillations in cyclic gene regulatory networks. In Proceedings of the 48th IEEE Conference on Decision and Control held jointly with 2009 28th Chinese Control Conference, CDC/CCC 2009 (pp. 3521-3526). [5400718] (Proceedings of the IEEE Conference on Decision and Control). https://doi.org/10.1109/CDC.2009.5400718