Greater reductions in plasma aldosterone with aliskiren in hypertensive patients with higher soluble (Pro)renin receptor level

Kanako Bokuda, Satoshi Morimoto, Yasufumi Seki, Midori Yatabe, Daisuke Watanabe, Junichi Yatabe, Takashi Ando, Satoru Shimizu, Hiroshi Itoh, Atsuhiro Ichihara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The (pro)renin receptor is important in the regulation of the tissue renin-angiotensin-aldosterone system. The benefits and safety of single-aliskiren treatment without other renin-angiotensin-aldosterone system inhibitors remain unclear. The serum level of the soluble form of the (pro)renin receptor is thought to be a biomarker reflecting the activity of the tissue renin-angiotensin-aldosterone system. We investigated the effects of single renin-angiotensin-aldosterone system blockade with aliskiren on renal and vascular functions and determined if serum level of the soluble (pro)renin receptor was a predictor of aliskiren efficacy in hypertensive patients with chronic kidney disease. Thirty-nine essential hypertensive patients with chronic kidney disease in our outpatient clinic were randomly assigned to receive either aliskiren or amlodipine. The parameters associated with renal and vascular functions and indices of renin-angiotensin-aldosterone system components, including serum levels of the soluble form, were evaluated before and after 12-week and 24-week treatment. Blood pressure was not significantly different between the groups. No significant changes in serum levels were observed in the soluble (pro)renin receptor in either group. Urinary albumin, protein excretion, and cardio-ankle vascular index significantly decreased in the aliskiren group. In the aliskiren group, there was a significant negative correlation between the basal level of the soluble (pro)renin receptor and the change in plasma aldosterone concentration. Single renin-angiotensin-aldosterone system blockade with aliskiren showed renal and vascular protective effects independent of blood pressure reduction. Serum levels of the soluble (pro)renin receptor may indicate aldosterone production via the (pro)renin receptor in the adrenal gland.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalHypertension Research
DOIs
Publication statusAccepted/In press - 2018 Apr 4

Fingerprint

Aldosterone
Renin
Renin-Angiotensin System
Blood Vessels
Serum
Chronic Renal Insufficiency
Kidney
Blood Pressure
Amlodipine
Adrenal Glands
Ambulatory Care Facilities
aliskiren
Ankle
Albumins
Biomarkers
Safety
Therapeutics
Proteins

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Greater reductions in plasma aldosterone with aliskiren in hypertensive patients with higher soluble (Pro)renin receptor level. / Bokuda, Kanako; Morimoto, Satoshi; Seki, Yasufumi; Yatabe, Midori; Watanabe, Daisuke; Yatabe, Junichi; Ando, Takashi; Shimizu, Satoru; Itoh, Hiroshi; Ichihara, Atsuhiro.

In: Hypertension Research, 04.04.2018, p. 1-9.

Research output: Contribution to journalArticle

Bokuda, Kanako ; Morimoto, Satoshi ; Seki, Yasufumi ; Yatabe, Midori ; Watanabe, Daisuke ; Yatabe, Junichi ; Ando, Takashi ; Shimizu, Satoru ; Itoh, Hiroshi ; Ichihara, Atsuhiro. / Greater reductions in plasma aldosterone with aliskiren in hypertensive patients with higher soluble (Pro)renin receptor level. In: Hypertension Research. 2018 ; pp. 1-9.
@article{9ec06fbc00f44b7ba2a54a669dc66a0e,
title = "Greater reductions in plasma aldosterone with aliskiren in hypertensive patients with higher soluble (Pro)renin receptor level",
abstract = "The (pro)renin receptor is important in the regulation of the tissue renin-angiotensin-aldosterone system. The benefits and safety of single-aliskiren treatment without other renin-angiotensin-aldosterone system inhibitors remain unclear. The serum level of the soluble form of the (pro)renin receptor is thought to be a biomarker reflecting the activity of the tissue renin-angiotensin-aldosterone system. We investigated the effects of single renin-angiotensin-aldosterone system blockade with aliskiren on renal and vascular functions and determined if serum level of the soluble (pro)renin receptor was a predictor of aliskiren efficacy in hypertensive patients with chronic kidney disease. Thirty-nine essential hypertensive patients with chronic kidney disease in our outpatient clinic were randomly assigned to receive either aliskiren or amlodipine. The parameters associated with renal and vascular functions and indices of renin-angiotensin-aldosterone system components, including serum levels of the soluble form, were evaluated before and after 12-week and 24-week treatment. Blood pressure was not significantly different between the groups. No significant changes in serum levels were observed in the soluble (pro)renin receptor in either group. Urinary albumin, protein excretion, and cardio-ankle vascular index significantly decreased in the aliskiren group. In the aliskiren group, there was a significant negative correlation between the basal level of the soluble (pro)renin receptor and the change in plasma aldosterone concentration. Single renin-angiotensin-aldosterone system blockade with aliskiren showed renal and vascular protective effects independent of blood pressure reduction. Serum levels of the soluble (pro)renin receptor may indicate aldosterone production via the (pro)renin receptor in the adrenal gland.",
author = "Kanako Bokuda and Satoshi Morimoto and Yasufumi Seki and Midori Yatabe and Daisuke Watanabe and Junichi Yatabe and Takashi Ando and Satoru Shimizu and Hiroshi Itoh and Atsuhiro Ichihara",
year = "2018",
month = "4",
day = "4",
doi = "10.1038/s41440-018-0037-1",
language = "English",
pages = "1--9",
journal = "Hypertension Research",
issn = "0916-9636",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Greater reductions in plasma aldosterone with aliskiren in hypertensive patients with higher soluble (Pro)renin receptor level

AU - Bokuda, Kanako

AU - Morimoto, Satoshi

AU - Seki, Yasufumi

AU - Yatabe, Midori

AU - Watanabe, Daisuke

AU - Yatabe, Junichi

AU - Ando, Takashi

AU - Shimizu, Satoru

AU - Itoh, Hiroshi

AU - Ichihara, Atsuhiro

PY - 2018/4/4

Y1 - 2018/4/4

N2 - The (pro)renin receptor is important in the regulation of the tissue renin-angiotensin-aldosterone system. The benefits and safety of single-aliskiren treatment without other renin-angiotensin-aldosterone system inhibitors remain unclear. The serum level of the soluble form of the (pro)renin receptor is thought to be a biomarker reflecting the activity of the tissue renin-angiotensin-aldosterone system. We investigated the effects of single renin-angiotensin-aldosterone system blockade with aliskiren on renal and vascular functions and determined if serum level of the soluble (pro)renin receptor was a predictor of aliskiren efficacy in hypertensive patients with chronic kidney disease. Thirty-nine essential hypertensive patients with chronic kidney disease in our outpatient clinic were randomly assigned to receive either aliskiren or amlodipine. The parameters associated with renal and vascular functions and indices of renin-angiotensin-aldosterone system components, including serum levels of the soluble form, were evaluated before and after 12-week and 24-week treatment. Blood pressure was not significantly different between the groups. No significant changes in serum levels were observed in the soluble (pro)renin receptor in either group. Urinary albumin, protein excretion, and cardio-ankle vascular index significantly decreased in the aliskiren group. In the aliskiren group, there was a significant negative correlation between the basal level of the soluble (pro)renin receptor and the change in plasma aldosterone concentration. Single renin-angiotensin-aldosterone system blockade with aliskiren showed renal and vascular protective effects independent of blood pressure reduction. Serum levels of the soluble (pro)renin receptor may indicate aldosterone production via the (pro)renin receptor in the adrenal gland.

AB - The (pro)renin receptor is important in the regulation of the tissue renin-angiotensin-aldosterone system. The benefits and safety of single-aliskiren treatment without other renin-angiotensin-aldosterone system inhibitors remain unclear. The serum level of the soluble form of the (pro)renin receptor is thought to be a biomarker reflecting the activity of the tissue renin-angiotensin-aldosterone system. We investigated the effects of single renin-angiotensin-aldosterone system blockade with aliskiren on renal and vascular functions and determined if serum level of the soluble (pro)renin receptor was a predictor of aliskiren efficacy in hypertensive patients with chronic kidney disease. Thirty-nine essential hypertensive patients with chronic kidney disease in our outpatient clinic were randomly assigned to receive either aliskiren or amlodipine. The parameters associated with renal and vascular functions and indices of renin-angiotensin-aldosterone system components, including serum levels of the soluble form, were evaluated before and after 12-week and 24-week treatment. Blood pressure was not significantly different between the groups. No significant changes in serum levels were observed in the soluble (pro)renin receptor in either group. Urinary albumin, protein excretion, and cardio-ankle vascular index significantly decreased in the aliskiren group. In the aliskiren group, there was a significant negative correlation between the basal level of the soluble (pro)renin receptor and the change in plasma aldosterone concentration. Single renin-angiotensin-aldosterone system blockade with aliskiren showed renal and vascular protective effects independent of blood pressure reduction. Serum levels of the soluble (pro)renin receptor may indicate aldosterone production via the (pro)renin receptor in the adrenal gland.

UR - http://www.scopus.com/inward/record.url?scp=85044931892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044931892&partnerID=8YFLogxK

U2 - 10.1038/s41440-018-0037-1

DO - 10.1038/s41440-018-0037-1

M3 - Article

SP - 1

EP - 9

JO - Hypertension Research

JF - Hypertension Research

SN - 0916-9636

ER -