Griseoviridin and cyclic hydroxamates found in a screening program for wnt signal inhibitor

Yuuya Tamai, Kazufumi Toume, Midori A. Arai, Masami Ishibashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A screening study using a luciferase assay to identify natural products which inhibit Wnt signaling was carried out. Bioassay-guided fractionation of the culture broth and mycelia of actinomycetes CKK748 and CKK784, led to the isolation of griseoviridin (1), and four cyclic hydroxamates (4-7) as active compounds. 1, 4, and 5 inhibited TCF/β-catenin transcriptional activity with IC50 values of 8.2-14 μM.

Original languageEnglish
Pages (from-to)1517-1524
Number of pages8
JournalHeterocycles
Volume86
Issue number2
DOIs
Publication statusPublished - 2012 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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