Abstract
A screening study using a luciferase assay to identify natural products which inhibit Wnt signaling was carried out. Bioassay-guided fractionation of the culture broth and mycelia of actinomycetes CKK748 and CKK784, led to the isolation of griseoviridin (1), and four cyclic hydroxamates (4-7) as active compounds. 1, 4, and 5 inhibited TCF/β-catenin transcriptional activity with IC50 values of 8.2-14 μM.
Original language | English |
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Pages (from-to) | 1517-1524 |
Number of pages | 8 |
Journal | Heterocycles |
Volume | 86 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry