Griseoviridin and cyclic hydroxamates found in a screening program for wnt signal inhibitor

Yuuya Tamai; Kazufumi Toume; Midori A. Arai; Masami Ishibashi

doi:10.3987/COM-12-S(N)64

Griseoviridin and cyclic hydroxamates found in a screening program for wnt signal inhibitor

Yuuya Tamai, Kazufumi Toume, Midori A. Arai, Masami Ishibashi

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

A screening study using a luciferase assay to identify natural products which inhibit Wnt signaling was carried out. Bioassay-guided fractionation of the culture broth and mycelia of actinomycetes CKK748 and CKK784, led to the isolation of griseoviridin (1), and four cyclic hydroxamates (4-7) as active compounds. 1, 4, and 5 inhibited TCF/β-catenin transcriptional activity with IC50 values of 8.2-14 μM.

Original language	English
Pages (from-to)	1517-1524
Number of pages	8
Journal	Heterocycles
Volume	86
Issue number	2
DOIs	https://doi.org/10.3987/COM-12-S(N)64
Publication status	Published - 2012 Dec 1
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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AU - Arai, Midori A.

AU - Ishibashi, Masami

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AB - A screening study using a luciferase assay to identify natural products which inhibit Wnt signaling was carried out. Bioassay-guided fractionation of the culture broth and mycelia of actinomycetes CKK748 and CKK784, led to the isolation of griseoviridin (1), and four cyclic hydroxamates (4-7) as active compounds. 1, 4, and 5 inhibited TCF/β-catenin transcriptional activity with IC50 values of 8.2-14 μM.

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