Growth of human tumor xenografts in nude mice and mice with severe combined immunodeficiency (SCID)

Tetsuro Kubota, Hiroshi Yamaguchi, Masahiko Watanabe, Takaaki Yamamoto, Tetsuya Takahara, Tooru Takeuchi, Toshiharu Furukawa, Suguru Kase, Susumu Kodaira, Kyuya Ishibiki, Masaki Kitajima

Research output: Contribution to journalArticle

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Abstract

Twenty-three fresh tumor specimens obtained at surgery and 5 serially transferable human tumor xenografts were implanted subcutaneously into nude mice and mice with severe combined immunodeficiency (SCID) to compare the take rates of the fresh surgical specimens and the growth rates of the transferable strains. The overall take rates were 65% for the SCID mice and 60% for the nude mice, without any significant difference, although colon carcinoma seemed to have higher acceptance in the SCID mice with a take rate of 6/8. All the serially transferable strains were successfully accepted in the SCID mice, their growth rates being essentially identical to those in the nude mice. These results indicate that the SCID mouse can be used as a human tumor xenograft-mouse system as well as the nude mouse.

Original languageEnglish
Pages (from-to)375-377
Number of pages3
JournalSurgery Today
Volume23
Issue number4
DOIs
Publication statusPublished - 1993 Apr

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Severe Combined Immunodeficiency
Heterografts
Nude Mice
Growth
Neoplasms
Colon
Carcinoma

Keywords

  • human tumor xenografts
  • nude mouse
  • SCID mouse

ASJC Scopus subject areas

  • Surgery

Cite this

Kubota, T., Yamaguchi, H., Watanabe, M., Yamamoto, T., Takahara, T., Takeuchi, T., ... Kitajima, M. (1993). Growth of human tumor xenografts in nude mice and mice with severe combined immunodeficiency (SCID). Surgery Today, 23(4), 375-377. https://doi.org/10.1007/BF00309059

Growth of human tumor xenografts in nude mice and mice with severe combined immunodeficiency (SCID). / Kubota, Tetsuro; Yamaguchi, Hiroshi; Watanabe, Masahiko; Yamamoto, Takaaki; Takahara, Tetsuya; Takeuchi, Tooru; Furukawa, Toshiharu; Kase, Suguru; Kodaira, Susumu; Ishibiki, Kyuya; Kitajima, Masaki.

In: Surgery Today, Vol. 23, No. 4, 04.1993, p. 375-377.

Research output: Contribution to journalArticle

Kubota, T, Yamaguchi, H, Watanabe, M, Yamamoto, T, Takahara, T, Takeuchi, T, Furukawa, T, Kase, S, Kodaira, S, Ishibiki, K & Kitajima, M 1993, 'Growth of human tumor xenografts in nude mice and mice with severe combined immunodeficiency (SCID)', Surgery Today, vol. 23, no. 4, pp. 375-377. https://doi.org/10.1007/BF00309059
Kubota T, Yamaguchi H, Watanabe M, Yamamoto T, Takahara T, Takeuchi T et al. Growth of human tumor xenografts in nude mice and mice with severe combined immunodeficiency (SCID). Surgery Today. 1993 Apr;23(4):375-377. https://doi.org/10.1007/BF00309059
Kubota, Tetsuro ; Yamaguchi, Hiroshi ; Watanabe, Masahiko ; Yamamoto, Takaaki ; Takahara, Tetsuya ; Takeuchi, Tooru ; Furukawa, Toshiharu ; Kase, Suguru ; Kodaira, Susumu ; Ishibiki, Kyuya ; Kitajima, Masaki. / Growth of human tumor xenografts in nude mice and mice with severe combined immunodeficiency (SCID). In: Surgery Today. 1993 ; Vol. 23, No. 4. pp. 375-377.
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