Growth rate of lung cancer recognized as small solid nodule on initial CT findings

Kei Mikita, Haruhiro Saito, Yuji Sakuma, Tetsuro Kondo, Takeshi Honda, Syuji Murakami, Fumihiro Oshita, Hiroyuki Ito, Masahiro Tsuboi, Haruhiko Nakayama, Tomoyuki Yokose, Yoichi Kameda, Kazumasa Noda, Kouzo Yamada

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13 Citations (Scopus)

Abstract

To study the characteristics of lung cancer, appearing as small solid nodules on initial computed tomography (CT) findings, and to determine an appropriate follow-up duration so as to differentiate between malignancy and benign tumor. Methods: We analyzed the records of 34 patients who had undergone surgical resection of lung cancer, which appeared as small solid nodules on initial CT findings. We studied the CT findings, volume doubling times (VDT), follow-up durations, pathological and clinical findings. Results: VDT is classified as follows: (1) slow growth group (SGG), with a VDT of more than 700 days and (2) rapid growth group (RGG), with a VDT of less than 700 days. The median VDT of the SGG was 1083 days, and the RGG was 256 days (p < 0.01). The median duration for follow-up of the SGG was 1218 days, and 179 days for the RGG. A statistical difference was noted in the follow-up durations (p < 0.01). There were no statistical differences in the preoperative thin-section CT (TSCT) findings, or in the pathological findings. The RGG included more patients with smoking histories. The CT findings of RGG tended to reveal changed in base lung field such as emphysema, and lung fibrosis. Conclusions: Generally, lung cancer appearing as small solid nodules on initial CT findings grew rapidly, but there were some cases which displayed slow growth patterns. These cases required follow up for over two years, before diagnosis was possible. We concluded the appropriate maximum followup duration is three years.

Original languageEnglish
Pages (from-to)e548-e553
JournalEuropean Journal of Radiology
Volume81
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1
Externally publishedYes

Keywords

  • Computed tomography (CT)
  • Follow up duration
  • Lung cancer
  • Solid nodule
  • Volume doubling time

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Mikita, K., Saito, H., Sakuma, Y., Kondo, T., Honda, T., Murakami, S., Oshita, F., Ito, H., Tsuboi, M., Nakayama, H., Yokose, T., Kameda, Y., Noda, K., & Yamada, K. (2012). Growth rate of lung cancer recognized as small solid nodule on initial CT findings. European Journal of Radiology, 81(4), e548-e553. https://doi.org/10.1016/j.ejrad.2011.06.032