Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ)

Keisuke Horiuchi, Hideo Morioka, Kazumasa Nishimoto, Yoshihisa Suzuki, Michiro Susa, Robert Nakayama, Akira Kawai, Hiroshi Sonobe, Hironari Takaishi, Toshifumi Ozaki, Hiroo Yabe, Kazuo Umezawa, Yoshiaki Toyama

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11 Citations (Scopus)

Abstract

Synovial sarcoma is a relatively common soft tissue sarcoma with an aggressive clinical course. Although surgery is currently the first treatment modality, improvement of adjuvant chemotherapy is deemed essential to improve the clinical outcome. Nuclear factor-κB (NF-κB) is constitutively activated in various cancer cells and has emerged as a potential therapeutic molecular target; however, the possible involvement of NF-κB in the pathology of sarcomas remains to be clarified. Herein we examined the effects of a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) on two synovial sarcoma-derived cell lines, HS-SY-II and SYO-1. The growth of both cell lines was completely inhibited by DHMEQ and apoptosis was induced at 10 μg/ml. Additionally, we found that DHMEQ showed additive effects when used in combination with other cytotoxic agents. These observations indicate that inhibition of NF-κB activity may serve as a potential therapeutic target for synovial sarcoma.

Original languageEnglish
Pages (from-to)336-344
Number of pages9
JournalCancer Letters
Volume272
Issue number2
DOIs
Publication statusPublished - 2008 Dec 18

Keywords

  • Chemotherapy
  • Dehydroxymethylepoxyquinomicin (DHMEQ)
  • NF-κB inhibitor
  • Synovial sarcoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Horiuchi, K., Morioka, H., Nishimoto, K., Suzuki, Y., Susa, M., Nakayama, R., Kawai, A., Sonobe, H., Takaishi, H., Ozaki, T., Yabe, H., Umezawa, K., & Toyama, Y. (2008). Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ). Cancer Letters, 272(2), 336-344. https://doi.org/10.1016/j.canlet.2008.07.021