Grubbs carbene complex-catalyzed cleavage of allyl vic-diols to aldehydes with a co-oxidant: Application to the selective cleavage of huge marine molecules

Chunguang Han, Yoshi Yamano, Fumitoshi Kakiuchi, Kazuhiko Nakamura, Daisuke Uemura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

An oxidative cleavage of allyl vic-diols to aldehydes catalyzed by a Grubbs carbene complex using a co-oxidant has been established for the first time, with good yields. The utility of this selective cleavage reaction was demonstrated through the use of two huge marine molecules, symbiodinolide and N-p-BrBz palytoxin.

Original languageEnglish
Pages (from-to)9622-9626
Number of pages5
JournalTetrahedron
Volume67
Issue number49
DOIs
Publication statusPublished - 2011 Dec 9

Keywords

  • Catalytic reaction
  • Degradation reaction
  • Grubbs carbene complex
  • Marine huge molecule

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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