Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

Junki Miyamoto, Miki Igarashi, Keita Watanabe, Shin ichiro Karaki, Hiromi Mukouyama, Shigenobu Kishino, Xuan Li, Atsuhiko Ichimura, Junichiro Irie, Yukihiko Sugimoto, Tetsuya Mizutani, Tatsuya Sugawara, Takashi Miki, Jun Ogawa, Daniel J. Drucker, Makoto Arita, Hiroshi Itoh, Ikuo Kimura

Research output: Contribution to journalArticle

Abstract

Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6 polyunsaturated fatty acid (PUFA) that is abundant in Western diet contributes to obesity and related diseases. Although gut-microbiota-related metabolic pathways of dietary PUFAs were recently elucidated, the effects on host physiological function remain unclear. Here, we demonstrate that gut microbiota confers host resistance to high-fat diet (HFD)-induced obesity by modulating dietary PUFAs metabolism. Supplementation of 10-hydroxy-cis-12-octadecenoic acid (HYA), an initial linoleic acid-related gut-microbial metabolite, attenuates HFD-induced obesity in mice without eliciting arachidonic acid-mediated adipose inflammation and by improving metabolic condition via free fatty acid receptors. Moreover, Lactobacillus-colonized mice show similar effects with elevated HYA levels. Our findings illustrate the interplay between gut microbiota and host energy metabolism via the metabolites of dietary omega-6-FAs thereby shedding light on the prevention and treatment of metabolic disorders by targeting gut microbial metabolites.

Original languageEnglish
Article number4007
JournalNature communications
Volume10
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

Fingerprint

obesity
diets
fatty acids
Nutrition
Unsaturated Fatty Acids
metabolites
metabolism
Metabolites
Obesity
acids
fats
High Fat Diet
Metabolism
mice
Omega-6 Fatty Acids
Fats
disorders
Lactobacillus
Linoleic Acid
Metabolic Networks and Pathways

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Miyamoto, J., Igarashi, M., Watanabe, K., Karaki, S. I., Mukouyama, H., Kishino, S., ... Kimura, I. (2019). Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids. Nature communications, 10(1), [4007]. https://doi.org/10.1038/s41467-019-11978-0

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids. / Miyamoto, Junki; Igarashi, Miki; Watanabe, Keita; Karaki, Shin ichiro; Mukouyama, Hiromi; Kishino, Shigenobu; Li, Xuan; Ichimura, Atsuhiko; Irie, Junichiro; Sugimoto, Yukihiko; Mizutani, Tetsuya; Sugawara, Tatsuya; Miki, Takashi; Ogawa, Jun; Drucker, Daniel J.; Arita, Makoto; Itoh, Hiroshi; Kimura, Ikuo.

In: Nature communications, Vol. 10, No. 1, 4007, 01.12.2019.

Research output: Contribution to journalArticle

Miyamoto, J, Igarashi, M, Watanabe, K, Karaki, SI, Mukouyama, H, Kishino, S, Li, X, Ichimura, A, Irie, J, Sugimoto, Y, Mizutani, T, Sugawara, T, Miki, T, Ogawa, J, Drucker, DJ, Arita, M, Itoh, H & Kimura, I 2019, 'Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids', Nature communications, vol. 10, no. 1, 4007. https://doi.org/10.1038/s41467-019-11978-0
Miyamoto, Junki ; Igarashi, Miki ; Watanabe, Keita ; Karaki, Shin ichiro ; Mukouyama, Hiromi ; Kishino, Shigenobu ; Li, Xuan ; Ichimura, Atsuhiko ; Irie, Junichiro ; Sugimoto, Yukihiko ; Mizutani, Tetsuya ; Sugawara, Tatsuya ; Miki, Takashi ; Ogawa, Jun ; Drucker, Daniel J. ; Arita, Makoto ; Itoh, Hiroshi ; Kimura, Ikuo. / Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids. In: Nature communications. 2019 ; Vol. 10, No. 1.
@article{3ac1b0931792404cb4378de0108d158c,
title = "Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids",
abstract = "Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6 polyunsaturated fatty acid (PUFA) that is abundant in Western diet contributes to obesity and related diseases. Although gut-microbiota-related metabolic pathways of dietary PUFAs were recently elucidated, the effects on host physiological function remain unclear. Here, we demonstrate that gut microbiota confers host resistance to high-fat diet (HFD)-induced obesity by modulating dietary PUFAs metabolism. Supplementation of 10-hydroxy-cis-12-octadecenoic acid (HYA), an initial linoleic acid-related gut-microbial metabolite, attenuates HFD-induced obesity in mice without eliciting arachidonic acid-mediated adipose inflammation and by improving metabolic condition via free fatty acid receptors. Moreover, Lactobacillus-colonized mice show similar effects with elevated HYA levels. Our findings illustrate the interplay between gut microbiota and host energy metabolism via the metabolites of dietary omega-6-FAs thereby shedding light on the prevention and treatment of metabolic disorders by targeting gut microbial metabolites.",
author = "Junki Miyamoto and Miki Igarashi and Keita Watanabe and Karaki, {Shin ichiro} and Hiromi Mukouyama and Shigenobu Kishino and Xuan Li and Atsuhiko Ichimura and Junichiro Irie and Yukihiko Sugimoto and Tetsuya Mizutani and Tatsuya Sugawara and Takashi Miki and Jun Ogawa and Drucker, {Daniel J.} and Makoto Arita and Hiroshi Itoh and Ikuo Kimura",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41467-019-11978-0",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

AU - Miyamoto, Junki

AU - Igarashi, Miki

AU - Watanabe, Keita

AU - Karaki, Shin ichiro

AU - Mukouyama, Hiromi

AU - Kishino, Shigenobu

AU - Li, Xuan

AU - Ichimura, Atsuhiko

AU - Irie, Junichiro

AU - Sugimoto, Yukihiko

AU - Mizutani, Tetsuya

AU - Sugawara, Tatsuya

AU - Miki, Takashi

AU - Ogawa, Jun

AU - Drucker, Daniel J.

AU - Arita, Makoto

AU - Itoh, Hiroshi

AU - Kimura, Ikuo

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6 polyunsaturated fatty acid (PUFA) that is abundant in Western diet contributes to obesity and related diseases. Although gut-microbiota-related metabolic pathways of dietary PUFAs were recently elucidated, the effects on host physiological function remain unclear. Here, we demonstrate that gut microbiota confers host resistance to high-fat diet (HFD)-induced obesity by modulating dietary PUFAs metabolism. Supplementation of 10-hydroxy-cis-12-octadecenoic acid (HYA), an initial linoleic acid-related gut-microbial metabolite, attenuates HFD-induced obesity in mice without eliciting arachidonic acid-mediated adipose inflammation and by improving metabolic condition via free fatty acid receptors. Moreover, Lactobacillus-colonized mice show similar effects with elevated HYA levels. Our findings illustrate the interplay between gut microbiota and host energy metabolism via the metabolites of dietary omega-6-FAs thereby shedding light on the prevention and treatment of metabolic disorders by targeting gut microbial metabolites.

AB - Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6 polyunsaturated fatty acid (PUFA) that is abundant in Western diet contributes to obesity and related diseases. Although gut-microbiota-related metabolic pathways of dietary PUFAs were recently elucidated, the effects on host physiological function remain unclear. Here, we demonstrate that gut microbiota confers host resistance to high-fat diet (HFD)-induced obesity by modulating dietary PUFAs metabolism. Supplementation of 10-hydroxy-cis-12-octadecenoic acid (HYA), an initial linoleic acid-related gut-microbial metabolite, attenuates HFD-induced obesity in mice without eliciting arachidonic acid-mediated adipose inflammation and by improving metabolic condition via free fatty acid receptors. Moreover, Lactobacillus-colonized mice show similar effects with elevated HYA levels. Our findings illustrate the interplay between gut microbiota and host energy metabolism via the metabolites of dietary omega-6-FAs thereby shedding light on the prevention and treatment of metabolic disorders by targeting gut microbial metabolites.

UR - http://www.scopus.com/inward/record.url?scp=85071762031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071762031&partnerID=8YFLogxK

U2 - 10.1038/s41467-019-11978-0

DO - 10.1038/s41467-019-11978-0

M3 - Article

C2 - 31488836

AN - SCOPUS:85071762031

VL - 10

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4007

ER -