Gut microbiota-generated metabolites in animal health and disease

Won Jae Lee, Kouji Hase

Research output: Contribution to journalArticle

218 Citations (Scopus)

Abstract

Gut microbiota is found in virtually any metazoan, from invertebrates to vertebrates. It has long been believed that gut microbiota, more specifically, the activity of the microbiome and its metabolic products, directly influence a variety of aspects in metazoan physiology. However, the exact molecular relationship among microbe-derived gut metabolites, host signaling pathways, and host physiology remains to be elucidated. Here we review recent discoveries regarding the molecular links between gut metabolites and host physiology in different invertebrate and vertebrate animal models. We describe the different roles of gut microbiome activity and their metabolites in regulating distinct host physiology and the molecular mechanisms by which gut metabolites cause physiological homeostasis via regulating specific host signaling pathways. Future studies in this direction using different animal models will provide the key concepts to understanding the evolutionarily conserved chemical dialogues between gut microbiota and metazoan cells and also human diseases associated with gut microbiota and metabolites.

Original languageEnglish
Pages (from-to)416-424
Number of pages9
JournalNature Chemical Biology
Volume10
Issue number6
DOIs
Publication statusPublished - 2014

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Animal Diseases
Health
Invertebrates
Vertebrates
Animal Models
Microbiota
Homeostasis
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Gut microbiota-generated metabolites in animal health and disease. / Lee, Won Jae; Hase, Kouji.

In: Nature Chemical Biology, Vol. 10, No. 6, 2014, p. 416-424.

Research output: Contribution to journalArticle

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