Gynecologic Cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the ovary

Aikou Okamoto, Rosalind M. Glasspool, Seiji Mabuchi, Noriomi Matsumura, Hiroyuki Nomura, Hiroaki Itamochi, Masashi Takano, Tadao Takano, Nobuyuki Susumu, Daisuke Aoki, Ikuo Konishi, Alan Covens, Jonathan Ledermann, Delia Mezzazanica, Christopher Steer, David Millan, Iain A. McNeish, Jacobus Pfisterer, Sokbom Kang, Laurence GladieffJane Bryce, Amit Oza

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Clear cell carcinoma of the ovary (CCC) is a histologic subtype of epithelial ovarian cancer with a distinct clinical behavior. There are marked geographic differences in the prevalence of CCC. The CCC is more likely to be detected at an early stage than high-grade serous cancers, and when confined within the ovary, the prognosis is good. However, advanced disease is associated with a very poor prognosis and resistance to standard treatment. Cytoreductive surgery should be performed for patients with stage II, III, or IV disease. An international phase III study to compare irinotecan/cisplatin and paclitaxel/carboplatin as adjuvant chemotherapy for stage IIV CCC has completed enrollment (GCIG/JGOG3017). Considering the frequent PIK3CA mutation in CCC, dual inhibitors targeting PI3K, AKT in the mTOR pathway, are promising. Performing these trials and generating the evidence will require considerable international collaboration.

Original languageEnglish
Pages (from-to)S20-S25
JournalInternational Journal of Gynecological Cancer
Volume24
Issue number9
DOIs
Publication statusPublished - 2014 Nov 1

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Ovary
Carcinoma
Neoplasms
irinotecan
Carboplatin
Adjuvant Chemotherapy
Phosphatidylinositol 3-Kinases
Mutation
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Okamoto, A., Glasspool, R. M., Mabuchi, S., Matsumura, N., Nomura, H., Itamochi, H., ... Oza, A. (2014). Gynecologic Cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the ovary. International Journal of Gynecological Cancer, 24(9), S20-S25. https://doi.org/10.1097/IGC.0000000000000289

Gynecologic Cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the ovary. / Okamoto, Aikou; Glasspool, Rosalind M.; Mabuchi, Seiji; Matsumura, Noriomi; Nomura, Hiroyuki; Itamochi, Hiroaki; Takano, Masashi; Takano, Tadao; Susumu, Nobuyuki; Aoki, Daisuke; Konishi, Ikuo; Covens, Alan; Ledermann, Jonathan; Mezzazanica, Delia; Steer, Christopher; Millan, David; McNeish, Iain A.; Pfisterer, Jacobus; Kang, Sokbom; Gladieff, Laurence; Bryce, Jane; Oza, Amit.

In: International Journal of Gynecological Cancer, Vol. 24, No. 9, 01.11.2014, p. S20-S25.

Research output: Contribution to journalArticle

Okamoto, A, Glasspool, RM, Mabuchi, S, Matsumura, N, Nomura, H, Itamochi, H, Takano, M, Takano, T, Susumu, N, Aoki, D, Konishi, I, Covens, A, Ledermann, J, Mezzazanica, D, Steer, C, Millan, D, McNeish, IA, Pfisterer, J, Kang, S, Gladieff, L, Bryce, J & Oza, A 2014, 'Gynecologic Cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the ovary', International Journal of Gynecological Cancer, vol. 24, no. 9, pp. S20-S25. https://doi.org/10.1097/IGC.0000000000000289
Okamoto, Aikou ; Glasspool, Rosalind M. ; Mabuchi, Seiji ; Matsumura, Noriomi ; Nomura, Hiroyuki ; Itamochi, Hiroaki ; Takano, Masashi ; Takano, Tadao ; Susumu, Nobuyuki ; Aoki, Daisuke ; Konishi, Ikuo ; Covens, Alan ; Ledermann, Jonathan ; Mezzazanica, Delia ; Steer, Christopher ; Millan, David ; McNeish, Iain A. ; Pfisterer, Jacobus ; Kang, Sokbom ; Gladieff, Laurence ; Bryce, Jane ; Oza, Amit. / Gynecologic Cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the ovary. In: International Journal of Gynecological Cancer. 2014 ; Vol. 24, No. 9. pp. S20-S25.
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