H1FOO is coupled to the initiation of oocytic growth

Mamoru Tanaka, Maki Kihara, Jon D. Hennebold, John J. Eppig, Maria M. Viveiros, Benjamin R. Emery, Douglas T. Carrell, Nikki J. Kirkman, Blazej Meczekalski, Jian Zhou, Carolyn A. Bondy, Matthias Becker, Richard M. Schultz, Tom Misteli, Rabindranath De La Fuente, Gretchen J. King, Eli Y. Adashi

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We previously reported the discovery of a novel mammalian H1 linker histone termed H1FOO (formerly H1OO), a replacement H1, the expression of which is restricted to the growing/maturing oocyte and to the zygote. The significance of this pre-embryonic H1 draws on its substantial orthologous conservation, singular structural attributes, selectivity for the germ cell lineage, prolonged nucleosomal residence, and apparent predominance among germ cell H1s. Herein, we report that the intronic, single-copy, five-exon (≥5301 base pair) H1foo gene maps to chromosome 6 and that the corresponding primary H1foo transcript gives rise to two distinct, alternatively spliced mRNA species (H1foo α and H1fooβ). The expression of the oocytic H1FOO transcript and protein proved temporally coupled to the recruitment of resting primordial follicles into a developing primary follicular cohort and thus to the critical transition marking the onset of oocytic growth. The corresponding potential protein isoforms (H1FOOα and H1FOO β), both nuclear localization sequence-endowed but export consensus sequence-free and possessing a significant net positive charge, localized primarily to perinucleolar heterochromatin in the oocytic germinal vesicle. Further investigation will be required to define the functional role of the H1FOO protein in the ordering of the chromatin of early mammalian development as well as its potential role in defining the primordial-to-primary follicle transition.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalBiology of Reproduction
Volume72
Issue number1
DOIs
Publication statusPublished - 2005 Jan

Fingerprint

Germ Cells
Chromosomes, Human, Pair 6
Heterochromatin
Zygote
Consensus Sequence
Cell Lineage
Growth
Base Pairing
Histones
Chromatin
Oocytes
Exons
Protein Isoforms
Proteins
Messenger RNA
Genes

Keywords

  • Meiosis
  • Oocyte development

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Embryology

Cite this

Tanaka, M., Kihara, M., Hennebold, J. D., Eppig, J. J., Viveiros, M. M., Emery, B. R., ... Adashi, E. Y. (2005). H1FOO is coupled to the initiation of oocytic growth. Biology of Reproduction, 72(1), 135-142. https://doi.org/10.1095/biolreprod.104.032474

H1FOO is coupled to the initiation of oocytic growth. / Tanaka, Mamoru; Kihara, Maki; Hennebold, Jon D.; Eppig, John J.; Viveiros, Maria M.; Emery, Benjamin R.; Carrell, Douglas T.; Kirkman, Nikki J.; Meczekalski, Blazej; Zhou, Jian; Bondy, Carolyn A.; Becker, Matthias; Schultz, Richard M.; Misteli, Tom; De La Fuente, Rabindranath; King, Gretchen J.; Adashi, Eli Y.

In: Biology of Reproduction, Vol. 72, No. 1, 01.2005, p. 135-142.

Research output: Contribution to journalArticle

Tanaka, M, Kihara, M, Hennebold, JD, Eppig, JJ, Viveiros, MM, Emery, BR, Carrell, DT, Kirkman, NJ, Meczekalski, B, Zhou, J, Bondy, CA, Becker, M, Schultz, RM, Misteli, T, De La Fuente, R, King, GJ & Adashi, EY 2005, 'H1FOO is coupled to the initiation of oocytic growth', Biology of Reproduction, vol. 72, no. 1, pp. 135-142. https://doi.org/10.1095/biolreprod.104.032474
Tanaka M, Kihara M, Hennebold JD, Eppig JJ, Viveiros MM, Emery BR et al. H1FOO is coupled to the initiation of oocytic growth. Biology of Reproduction. 2005 Jan;72(1):135-142. https://doi.org/10.1095/biolreprod.104.032474
Tanaka, Mamoru ; Kihara, Maki ; Hennebold, Jon D. ; Eppig, John J. ; Viveiros, Maria M. ; Emery, Benjamin R. ; Carrell, Douglas T. ; Kirkman, Nikki J. ; Meczekalski, Blazej ; Zhou, Jian ; Bondy, Carolyn A. ; Becker, Matthias ; Schultz, Richard M. ; Misteli, Tom ; De La Fuente, Rabindranath ; King, Gretchen J. ; Adashi, Eli Y. / H1FOO is coupled to the initiation of oocytic growth. In: Biology of Reproduction. 2005 ; Vol. 72, No. 1. pp. 135-142.
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