H1oo: A pre-embryonic H1 linker histone in search of a function

Mamoru Tanaka, Maki Kihara, Blazej Meczekalski, Gretchen J. King, Eli Y. Adashi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The mouse oocyte-specific linker histone H1oo (1) constitutes a novel mammalian homologue of the oocyte-specific linker histone B4 of the frog and of the cs-H1 linker histone of the sea urchin; (2) is expressed as early as the germinal vesicle (PI) stage oocyte, persisting into the MII stage oocyte, the oocytic polar bodies, and the 2-cell embryo, extinction becoming apparent at the 4-8 cell embryonic stage; and (3) may play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume202
Issue number1-2
DOIs
Publication statusPublished - 2003 Apr 28

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Keywords

  • H1oo
  • Maternal mRNA
  • Mouse oocyte
  • Occyte specific linker histone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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