H1oo

A pre-embryonic H1 linker histone in search of a function

Mamoru Tanaka, Maki Kihara, Blazej Meczekalski, Gretchen J. King, Eli Y. Adashi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The mouse oocyte-specific linker histone H1oo (1) constitutes a novel mammalian homologue of the oocyte-specific linker histone B4 of the frog and of the cs-H1 linker histone of the sea urchin; (2) is expressed as early as the germinal vesicle (PI) stage oocyte, persisting into the MII stage oocyte, the oocytic polar bodies, and the 2-cell embryo, extinction becoming apparent at the 4-8 cell embryonic stage; and (3) may play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume202
Issue number1-2
DOIs
Publication statusPublished - 2003 Apr 28

Fingerprint

Histones
Oocytes
Polar Bodies
Gene expression
Oogenesis
Chromatin
Sea Urchins
Anura
Embryonic Development
Embryonic Structures
Gene Expression

Keywords

  • H1oo
  • Maternal mRNA
  • Mouse oocyte
  • Occyte specific linker histone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

H1oo : A pre-embryonic H1 linker histone in search of a function. / Tanaka, Mamoru; Kihara, Maki; Meczekalski, Blazej; King, Gretchen J.; Adashi, Eli Y.

In: Molecular and Cellular Endocrinology, Vol. 202, No. 1-2, 28.04.2003, p. 5-9.

Research output: Contribution to journalArticle

Tanaka, Mamoru ; Kihara, Maki ; Meczekalski, Blazej ; King, Gretchen J. ; Adashi, Eli Y. / H1oo : A pre-embryonic H1 linker histone in search of a function. In: Molecular and Cellular Endocrinology. 2003 ; Vol. 202, No. 1-2. pp. 5-9.
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