Haemodynamic changes in non-alcoholic (viral) liver cirrhosis studied by computed tomography (CT) arterial portography and CT arteriography

Kenichi Takayasu, Kouichi Yoshie, Yukio Muramatsu, Ryoko Iwata, Yukihiro Nakanishi, Michiie Sakamoto, Haruhiko Fukuda, Mitsuo Satake, Noriyuki Moriyama, Yasuhiro Makino

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aims: To evaluate haemodynamic and vascular changes in non-alcoholic (viral) cirrhosis on conventional computed tomography (CT), CT arteriography (CTA) and CT arterial portography (CTAP), and to determine the cause of the observed reticular stain on angiography. Methods: Using surgically resected liver specimens from 31 patients with viral hepatitis associated hepatocellular carcinoma, images of conventional CT, CTA, CTAP and the sinusoidal phase of hepatic arteriography were retrospectively analysed and compared with pathology of the non-cancerous portion of the liver. Results: Computed tomography arteriography showed inhomogeneous enhancement (diffuse, low-density nodules) in a total of 16 samples (52%); in eight of 10 (80%) cirrhotic livers, three of six (50%) precirrhotic livers, five of 12 (42%) livers with chronic active hepatitis and none of three with no active liver disease. The frequency of inhomogeneous enhancement became significantly higher with increasing severity of parenchymal damage (P < 0.05). In contrast, conventional CT and CTAP showed homogeneous enhancement in all 31 (100%) patients. There was no correlation between inhomogeneous enhancement on CTA and reticular staining on sinusoidal-phase hepatic angiograms. Inhomogeneous enhancement was frequently seen in patients with hepatitis B surface antigen and/or anti-hepatitis C virus antibody compared with those without them (P < 0.05). Conclusion: The CTA was much more sensitive in detecting haemodynamic changes in the cirrhotic liver than CTAP, conventional CT and sinusoidal-phased hepatic angiography. Further study is required to clarify the mechanism of inhomogeneous enhancement on CTA and homogeneous enhancement on CTAP seen in cirrhosis.

Original languageEnglish
Pages (from-to)908-914
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume14
Issue number9
DOIs
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Portography
Liver Cirrhosis
Angiography
Hemodynamics
Tomography
Liver
Fibrosis
Hepatitis C Antibodies
Chronic Hepatitis
Hepatitis B Surface Antigens
Hepatitis
Blood Vessels
Liver Diseases
Hepatocellular Carcinoma
Coloring Agents

Keywords

  • Computed tomography arterial portography
  • Computed tomography arteriography
  • Haemodynamic changes
  • Inhomogeneous enhancement
  • Non-alcoholic cirrhosis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Haemodynamic changes in non-alcoholic (viral) liver cirrhosis studied by computed tomography (CT) arterial portography and CT arteriography. / Takayasu, Kenichi; Yoshie, Kouichi; Muramatsu, Yukio; Iwata, Ryoko; Nakanishi, Yukihiro; Sakamoto, Michiie; Fukuda, Haruhiko; Satake, Mitsuo; Moriyama, Noriyuki; Makino, Yasuhiro.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 14, No. 9, 1999, p. 908-914.

Research output: Contribution to journalArticle

Takayasu, Kenichi ; Yoshie, Kouichi ; Muramatsu, Yukio ; Iwata, Ryoko ; Nakanishi, Yukihiro ; Sakamoto, Michiie ; Fukuda, Haruhiko ; Satake, Mitsuo ; Moriyama, Noriyuki ; Makino, Yasuhiro. / Haemodynamic changes in non-alcoholic (viral) liver cirrhosis studied by computed tomography (CT) arterial portography and CT arteriography. In: Journal of Gastroenterology and Hepatology (Australia). 1999 ; Vol. 14, No. 9. pp. 908-914.
@article{b6d82a51337e42818ed55eef2efa1809,
title = "Haemodynamic changes in non-alcoholic (viral) liver cirrhosis studied by computed tomography (CT) arterial portography and CT arteriography",
abstract = "Aims: To evaluate haemodynamic and vascular changes in non-alcoholic (viral) cirrhosis on conventional computed tomography (CT), CT arteriography (CTA) and CT arterial portography (CTAP), and to determine the cause of the observed reticular stain on angiography. Methods: Using surgically resected liver specimens from 31 patients with viral hepatitis associated hepatocellular carcinoma, images of conventional CT, CTA, CTAP and the sinusoidal phase of hepatic arteriography were retrospectively analysed and compared with pathology of the non-cancerous portion of the liver. Results: Computed tomography arteriography showed inhomogeneous enhancement (diffuse, low-density nodules) in a total of 16 samples (52{\%}); in eight of 10 (80{\%}) cirrhotic livers, three of six (50{\%}) precirrhotic livers, five of 12 (42{\%}) livers with chronic active hepatitis and none of three with no active liver disease. The frequency of inhomogeneous enhancement became significantly higher with increasing severity of parenchymal damage (P < 0.05). In contrast, conventional CT and CTAP showed homogeneous enhancement in all 31 (100{\%}) patients. There was no correlation between inhomogeneous enhancement on CTA and reticular staining on sinusoidal-phase hepatic angiograms. Inhomogeneous enhancement was frequently seen in patients with hepatitis B surface antigen and/or anti-hepatitis C virus antibody compared with those without them (P < 0.05). Conclusion: The CTA was much more sensitive in detecting haemodynamic changes in the cirrhotic liver than CTAP, conventional CT and sinusoidal-phased hepatic angiography. Further study is required to clarify the mechanism of inhomogeneous enhancement on CTA and homogeneous enhancement on CTAP seen in cirrhosis.",
keywords = "Computed tomography arterial portography, Computed tomography arteriography, Haemodynamic changes, Inhomogeneous enhancement, Non-alcoholic cirrhosis",
author = "Kenichi Takayasu and Kouichi Yoshie and Yukio Muramatsu and Ryoko Iwata and Yukihiro Nakanishi and Michiie Sakamoto and Haruhiko Fukuda and Mitsuo Satake and Noriyuki Moriyama and Yasuhiro Makino",
year = "1999",
doi = "10.1046/j.1440-1746.1999.01957.x",
language = "English",
volume = "14",
pages = "908--914",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Haemodynamic changes in non-alcoholic (viral) liver cirrhosis studied by computed tomography (CT) arterial portography and CT arteriography

AU - Takayasu, Kenichi

AU - Yoshie, Kouichi

AU - Muramatsu, Yukio

AU - Iwata, Ryoko

AU - Nakanishi, Yukihiro

AU - Sakamoto, Michiie

AU - Fukuda, Haruhiko

AU - Satake, Mitsuo

AU - Moriyama, Noriyuki

AU - Makino, Yasuhiro

PY - 1999

Y1 - 1999

N2 - Aims: To evaluate haemodynamic and vascular changes in non-alcoholic (viral) cirrhosis on conventional computed tomography (CT), CT arteriography (CTA) and CT arterial portography (CTAP), and to determine the cause of the observed reticular stain on angiography. Methods: Using surgically resected liver specimens from 31 patients with viral hepatitis associated hepatocellular carcinoma, images of conventional CT, CTA, CTAP and the sinusoidal phase of hepatic arteriography were retrospectively analysed and compared with pathology of the non-cancerous portion of the liver. Results: Computed tomography arteriography showed inhomogeneous enhancement (diffuse, low-density nodules) in a total of 16 samples (52%); in eight of 10 (80%) cirrhotic livers, three of six (50%) precirrhotic livers, five of 12 (42%) livers with chronic active hepatitis and none of three with no active liver disease. The frequency of inhomogeneous enhancement became significantly higher with increasing severity of parenchymal damage (P < 0.05). In contrast, conventional CT and CTAP showed homogeneous enhancement in all 31 (100%) patients. There was no correlation between inhomogeneous enhancement on CTA and reticular staining on sinusoidal-phase hepatic angiograms. Inhomogeneous enhancement was frequently seen in patients with hepatitis B surface antigen and/or anti-hepatitis C virus antibody compared with those without them (P < 0.05). Conclusion: The CTA was much more sensitive in detecting haemodynamic changes in the cirrhotic liver than CTAP, conventional CT and sinusoidal-phased hepatic angiography. Further study is required to clarify the mechanism of inhomogeneous enhancement on CTA and homogeneous enhancement on CTAP seen in cirrhosis.

AB - Aims: To evaluate haemodynamic and vascular changes in non-alcoholic (viral) cirrhosis on conventional computed tomography (CT), CT arteriography (CTA) and CT arterial portography (CTAP), and to determine the cause of the observed reticular stain on angiography. Methods: Using surgically resected liver specimens from 31 patients with viral hepatitis associated hepatocellular carcinoma, images of conventional CT, CTA, CTAP and the sinusoidal phase of hepatic arteriography were retrospectively analysed and compared with pathology of the non-cancerous portion of the liver. Results: Computed tomography arteriography showed inhomogeneous enhancement (diffuse, low-density nodules) in a total of 16 samples (52%); in eight of 10 (80%) cirrhotic livers, three of six (50%) precirrhotic livers, five of 12 (42%) livers with chronic active hepatitis and none of three with no active liver disease. The frequency of inhomogeneous enhancement became significantly higher with increasing severity of parenchymal damage (P < 0.05). In contrast, conventional CT and CTAP showed homogeneous enhancement in all 31 (100%) patients. There was no correlation between inhomogeneous enhancement on CTA and reticular staining on sinusoidal-phase hepatic angiograms. Inhomogeneous enhancement was frequently seen in patients with hepatitis B surface antigen and/or anti-hepatitis C virus antibody compared with those without them (P < 0.05). Conclusion: The CTA was much more sensitive in detecting haemodynamic changes in the cirrhotic liver than CTAP, conventional CT and sinusoidal-phased hepatic angiography. Further study is required to clarify the mechanism of inhomogeneous enhancement on CTA and homogeneous enhancement on CTAP seen in cirrhosis.

KW - Computed tomography arterial portography

KW - Computed tomography arteriography

KW - Haemodynamic changes

KW - Inhomogeneous enhancement

KW - Non-alcoholic cirrhosis

UR - http://www.scopus.com/inward/record.url?scp=0032887071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032887071&partnerID=8YFLogxK

U2 - 10.1046/j.1440-1746.1999.01957.x

DO - 10.1046/j.1440-1746.1999.01957.x

M3 - Article

C2 - 10535474

AN - SCOPUS:0032887071

VL - 14

SP - 908

EP - 914

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 9

ER -