Haemostatic abnormalities in hepatosplenic schistosomiasis mansoni

Masanobu Tanabe

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Hepatosplenic schistosomiasis is a complex immuno-regulatory disease and is major health problem in endemic countries. Acute bleeding is one of its most serious complications and often life-threatening. Clinical studies have demonstrated that the patients with hepatosplenic schistosomiasis are prone to develop complex haemostatic abnormalities that may be linked to the potential risk of bleeding from ruptured esophageal varices in these patients. The deficit in haemostatic parameters is more pronounced with the advancement of the disease and is maximal in the patients with experience of haematomesis. Evidences of enhanced generation of thrombin and plasmin indicate the presence of low-grade DIC in advanced hepatosplenic schistosomiasis, which is considered as a principal cause of haemostatic abnormalities in this endemic disease. Demonstration of procoagulant expression in peripheral blood monocytes of the patients and in the livers, spleens and intestines of S. mansoni-infected mice suggest their possible implication in the causation of DIC in S. mansoni infections. Moreover, because in vitro analysis indicates a participation of immune mechanisms in the localized procoagulant expression, it seems likely that the immune responses to schstosomes play a major role in the pathogenic mechanisms of haemostatic abnormalities in hepatosplenic schistosomiasis.

Original languageEnglish
Pages (from-to)351-359
Number of pages9
JournalParasitology International
Volume52
Issue number4
DOIs
Publication statusPublished - 2003 Dec

Fingerprint

Schistosomiasis mansoni
Schistosomiasis
Hemostatics
Dacarbazine
Hemorrhage
Endemic Diseases
Esophageal and Gastric Varices
Fibrinolysin
Thrombin
Causality
Intestines
Monocytes
Spleen
Liver
Health
Infection

Keywords

  • Disseminated intravascular coagulation (DIC)
  • Haemostatic abnormalities
  • Macrophage
  • Procoagulant
  • Schistosoma mansoni
  • Schistosomiasis

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Haemostatic abnormalities in hepatosplenic schistosomiasis mansoni. / Tanabe, Masanobu.

In: Parasitology International, Vol. 52, No. 4, 12.2003, p. 351-359.

Research output: Contribution to journalArticle

Tanabe, Masanobu. / Haemostatic abnormalities in hepatosplenic schistosomiasis mansoni. In: Parasitology International. 2003 ; Vol. 52, No. 4. pp. 351-359.
@article{75ef8185589e4a4b935ec67b2c1e2549,
title = "Haemostatic abnormalities in hepatosplenic schistosomiasis mansoni",
abstract = "Hepatosplenic schistosomiasis is a complex immuno-regulatory disease and is major health problem in endemic countries. Acute bleeding is one of its most serious complications and often life-threatening. Clinical studies have demonstrated that the patients with hepatosplenic schistosomiasis are prone to develop complex haemostatic abnormalities that may be linked to the potential risk of bleeding from ruptured esophageal varices in these patients. The deficit in haemostatic parameters is more pronounced with the advancement of the disease and is maximal in the patients with experience of haematomesis. Evidences of enhanced generation of thrombin and plasmin indicate the presence of low-grade DIC in advanced hepatosplenic schistosomiasis, which is considered as a principal cause of haemostatic abnormalities in this endemic disease. Demonstration of procoagulant expression in peripheral blood monocytes of the patients and in the livers, spleens and intestines of S. mansoni-infected mice suggest their possible implication in the causation of DIC in S. mansoni infections. Moreover, because in vitro analysis indicates a participation of immune mechanisms in the localized procoagulant expression, it seems likely that the immune responses to schstosomes play a major role in the pathogenic mechanisms of haemostatic abnormalities in hepatosplenic schistosomiasis.",
keywords = "Disseminated intravascular coagulation (DIC), Haemostatic abnormalities, Macrophage, Procoagulant, Schistosoma mansoni, Schistosomiasis",
author = "Masanobu Tanabe",
year = "2003",
month = "12",
doi = "10.1016/S1383-5769(03)00051-5",
language = "English",
volume = "52",
pages = "351--359",
journal = "Parasitology International",
issn = "1383-5769",
publisher = "Elsevier Ireland Ltd",
number = "4",

}

TY - JOUR

T1 - Haemostatic abnormalities in hepatosplenic schistosomiasis mansoni

AU - Tanabe, Masanobu

PY - 2003/12

Y1 - 2003/12

N2 - Hepatosplenic schistosomiasis is a complex immuno-regulatory disease and is major health problem in endemic countries. Acute bleeding is one of its most serious complications and often life-threatening. Clinical studies have demonstrated that the patients with hepatosplenic schistosomiasis are prone to develop complex haemostatic abnormalities that may be linked to the potential risk of bleeding from ruptured esophageal varices in these patients. The deficit in haemostatic parameters is more pronounced with the advancement of the disease and is maximal in the patients with experience of haematomesis. Evidences of enhanced generation of thrombin and plasmin indicate the presence of low-grade DIC in advanced hepatosplenic schistosomiasis, which is considered as a principal cause of haemostatic abnormalities in this endemic disease. Demonstration of procoagulant expression in peripheral blood monocytes of the patients and in the livers, spleens and intestines of S. mansoni-infected mice suggest their possible implication in the causation of DIC in S. mansoni infections. Moreover, because in vitro analysis indicates a participation of immune mechanisms in the localized procoagulant expression, it seems likely that the immune responses to schstosomes play a major role in the pathogenic mechanisms of haemostatic abnormalities in hepatosplenic schistosomiasis.

AB - Hepatosplenic schistosomiasis is a complex immuno-regulatory disease and is major health problem in endemic countries. Acute bleeding is one of its most serious complications and often life-threatening. Clinical studies have demonstrated that the patients with hepatosplenic schistosomiasis are prone to develop complex haemostatic abnormalities that may be linked to the potential risk of bleeding from ruptured esophageal varices in these patients. The deficit in haemostatic parameters is more pronounced with the advancement of the disease and is maximal in the patients with experience of haematomesis. Evidences of enhanced generation of thrombin and plasmin indicate the presence of low-grade DIC in advanced hepatosplenic schistosomiasis, which is considered as a principal cause of haemostatic abnormalities in this endemic disease. Demonstration of procoagulant expression in peripheral blood monocytes of the patients and in the livers, spleens and intestines of S. mansoni-infected mice suggest their possible implication in the causation of DIC in S. mansoni infections. Moreover, because in vitro analysis indicates a participation of immune mechanisms in the localized procoagulant expression, it seems likely that the immune responses to schstosomes play a major role in the pathogenic mechanisms of haemostatic abnormalities in hepatosplenic schistosomiasis.

KW - Disseminated intravascular coagulation (DIC)

KW - Haemostatic abnormalities

KW - Macrophage

KW - Procoagulant

KW - Schistosoma mansoni

KW - Schistosomiasis

UR - http://www.scopus.com/inward/record.url?scp=0344665758&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344665758&partnerID=8YFLogxK

U2 - 10.1016/S1383-5769(03)00051-5

DO - 10.1016/S1383-5769(03)00051-5

M3 - Article

VL - 52

SP - 351

EP - 359

JO - Parasitology International

JF - Parasitology International

SN - 1383-5769

IS - 4

ER -