Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes

Yosuke Okamura, Ippei Maekawa, Toshinori Fujie, Shinji Takeoka, Makoto Handa, Yasuo Ikeda

Research output: Contribution to conferencePaper

Abstract

We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

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Keywords

  • Albumin
  • Fibrinogen γ chain dodecapeptide (H12)
  • Haemostatic effect
  • Platelet substitutes
  • Thrombocytopenic rats
  • Vesicles

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Okamura, Y., Maekawa, I., Fujie, T., Takeoka, S., Handa, M., & Ikeda, Y. (2005). Haemostatic effects of fibrinogen y chain dodecapeptide-conjugates as platelet substitutes. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.