Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota

Osamu Ohno; Tatsuhiko Chiba; Seiji Todoroki; Hideaki Yoshimura; Norihito Maru; Ken Maekawa; Hiroshi Imagawa; Kaoru Yamada; Atsushi Wakamiya; Kiyotake Suenaga; Daisuke Uemura

doi:10.1039/c1cc15557a

Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota

Osamu Ohno, Tatsuhiko Chiba, Seiji Todoroki, Hideaki Yoshimura, Norihito Maru, Ken Maekawa, Hiroshi Imagawa, Kaoru Yamada, Atsushi Wakamiya, Kiyotake Suenaga, Daisuke Uemura

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 induced apoptosis in HL60 human leukemia cells.

Original language	English
Pages (from-to)	12453-12455
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	46
DOIs	https://doi.org/10.1039/c1cc15557a
Publication status	Published - 2011 Dec 14

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc15557a

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title = "Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota",

abstract = "Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 induced apoptosis in HL60 human leukemia cells.",

author = "Osamu Ohno and Tatsuhiko Chiba and Seiji Todoroki and Hideaki Yoshimura and Norihito Maru and Ken Maekawa and Hiroshi Imagawa and Kaoru Yamada and Atsushi Wakamiya and Kiyotake Suenaga and Daisuke Uemura",

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doi = "10.1039/c1cc15557a",

language = "English",

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T1 - Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota

AU - Ohno, Osamu

AU - Chiba, Tatsuhiko

AU - Todoroki, Seiji

AU - Yoshimura, Hideaki

AU - Maru, Norihito

AU - Maekawa, Ken

AU - Imagawa, Hiroshi

AU - Yamada, Kaoru

AU - Wakamiya, Atsushi

AU - Suenaga, Kiyotake

AU - Uemura, Daisuke

PY - 2011/12/14

Y1 - 2011/12/14

N2 - Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 induced apoptosis in HL60 human leukemia cells.

AB - Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 induced apoptosis in HL60 human leukemia cells.

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VL - 47

SP - 12453

EP - 12455

JO - Chemical Communications

JF - Chemical Communications

IS - 46

ER -

Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota

Abstract

ASJC Scopus subject areas

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