Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota

Osamu Ohno, Tatsuhiko Chiba, Seiji Todoroki, Hideaki Yoshimura, Norihito Maru, Ken Maekawa, Hiroshi Imagawa, Kaoru Yamada, Atsushi Wakamiya, Kiyotake Suenaga, Daisuke Uemura

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 induced apoptosis in HL60 human leukemia cells.

Original languageEnglish
Pages (from-to)12453-12455
Number of pages3
JournalChemical Communications
Volume47
Issue number46
DOIs
Publication statusPublished - 2011 Dec 14

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Ohno, O., Chiba, T., Todoroki, S., Yoshimura, H., Maru, N., Maekawa, K., Imagawa, H., Yamada, K., Wakamiya, A., Suenaga, K., & Uemura, D. (2011). Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota. Chemical Communications, 47(46), 12453-12455. https://doi.org/10.1039/c1cc15557a