TY - GEN
T1 - Hand-Driven Device for Preparation of Linearly Aligned Hydrogel Sheets
AU - Kato, Aoi
AU - Oda, Haruka
AU - Takamori, Sho
AU - Mimura, Hisatoshi
AU - Osaki, Toshihisa
AU - Miki, Norihisa
AU - Takeuchi, Shoji
N1 - Funding Information:
This work was partly supported by JSPS KAKENHI Grant Number JP21H05013, and the Program for Building Regional Innovation Ecosystem of MEXT, Japan.
Publisher Copyright:
© 2023 IEEE.
PY - 2023
Y1 - 2023
N2 - In this paper, we present a three-layered device for preparation of heterologous core layers linearly aligned in a hydrogel sheet by a simple four-step process without using pumps. Recently, cell-based sensors have been developed for detection of odorant molecules owing to the sensitivity and selectivity of olfactory receptors to chemical substances. To detect various odorant molecules with these sensors, it is necessary to array multiple types of sensor cells expressing different olfactory receptors. We therefore propose a sheet-shaped sensor chip for a sensor-cell array. Previously, hydrogel sheets with heterogeneous cell patterns were produced using microfluidic devices with syringe pump systems, causing loss of both sample volumes and time for settings. Here, we develop a device that enables preparation of hydrogel sheets with a small amount of samples and with a single manual pipette.
AB - In this paper, we present a three-layered device for preparation of heterologous core layers linearly aligned in a hydrogel sheet by a simple four-step process without using pumps. Recently, cell-based sensors have been developed for detection of odorant molecules owing to the sensitivity and selectivity of olfactory receptors to chemical substances. To detect various odorant molecules with these sensors, it is necessary to array multiple types of sensor cells expressing different olfactory receptors. We therefore propose a sheet-shaped sensor chip for a sensor-cell array. Previously, hydrogel sheets with heterogeneous cell patterns were produced using microfluidic devices with syringe pump systems, causing loss of both sample volumes and time for settings. Here, we develop a device that enables preparation of hydrogel sheets with a small amount of samples and with a single manual pipette.
KW - Cell-based sensor
KW - Hydrogel sheet
KW - Insect olfactory receptor
KW - Surface tension
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U2 - 10.1109/MEMS49605.2023.10052320
DO - 10.1109/MEMS49605.2023.10052320
M3 - Conference contribution
AN - SCOPUS:85149886659
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 313
EP - 314
BT - 2023 IEEE 36th International Conference on Micro Electro Mechanical Systems, MEMS 2023
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 36th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2023
Y2 - 15 January 2023 through 19 January 2023
ER -