Haploidentical hematopoietic cell transplantation for disseminated Ewing sarcoma

Hiroki Yoshihara; Tadashi Kumamoto; Rintaro Ono; Keiko Akahane; Taiki Nozaki; Shogo Kobayashi; Atsushi Kikuta; Seiichi Matsumoto; Daisuke Hasegawa; Chitose Ogawa; Atsushi Manabe

doi:10.1111/ped.13195

Haploidentical hematopoietic cell transplantation for disseminated Ewing sarcoma

Hiroki Yoshihara, Tadashi Kumamoto, Rintaro Ono, Keiko Akahane, Taiki Nozaki, Shogo Kobayashi, Atsushi Kikuta, Seiichi Matsumoto, Daisuke Hasegawa, Chitose Ogawa, Atsushi Manabe

Research output: Contribution to journal › Article › peer-review

Abstract

We describe the case of a 13-year-old girl with multifocal disseminated Ewing sarcoma family of tumor (ESFT) who received a 5/8 human leukocyte antigen-matched haploidentical hematopoietic cell transplantation to generate a graft-versus-tumor effect. The patient had grade 2 acute graft-versus-host disease (GVHD) of the skin and chronic GVHD nausea and abdominal pain that required prednisolone for 17 months, but has been free from ESFT for 3 years 10 months after therapy. The present case suggests a beneficial effect of haploidentical hematopoietic cell transplantation in disseminated ESFT.

Original language	English
Pages (from-to)	223-226
Number of pages	4
Journal	Pediatrics International
Volume	59
Issue number	2
DOIs	https://doi.org/10.1111/ped.13195
Publication status	Published - 2017 Feb 1
Externally published	Yes

Keywords

Ewing sarcoma
graft-versus-host disease
graft-versus-tumor effect
hematopoietic stem cell transplantation
killer cell immunoglobulin-like receptor

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/ped.13195

Cite this

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abstract = "We describe the case of a 13-year-old girl with multifocal disseminated Ewing sarcoma family of tumor (ESFT) who received a 5/8 human leukocyte antigen-matched haploidentical hematopoietic cell transplantation to generate a graft-versus-tumor effect. The patient had grade 2 acute graft-versus-host disease (GVHD) of the skin and chronic GVHD nausea and abdominal pain that required prednisolone for 17 months, but has been free from ESFT for 3 years 10 months after therapy. The present case suggests a beneficial effect of haploidentical hematopoietic cell transplantation in disseminated ESFT.",

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AU - Yoshihara, Hiroki

AU - Kumamoto, Tadashi

AU - Ono, Rintaro

AU - Akahane, Keiko

AU - Nozaki, Taiki

AU - Kobayashi, Shogo

AU - Kikuta, Atsushi

AU - Matsumoto, Seiichi

AU - Hasegawa, Daisuke

AU - Ogawa, Chitose

AU - Manabe, Atsushi

PY - 2017/2/1

Y1 - 2017/2/1

N2 - We describe the case of a 13-year-old girl with multifocal disseminated Ewing sarcoma family of tumor (ESFT) who received a 5/8 human leukocyte antigen-matched haploidentical hematopoietic cell transplantation to generate a graft-versus-tumor effect. The patient had grade 2 acute graft-versus-host disease (GVHD) of the skin and chronic GVHD nausea and abdominal pain that required prednisolone for 17 months, but has been free from ESFT for 3 years 10 months after therapy. The present case suggests a beneficial effect of haploidentical hematopoietic cell transplantation in disseminated ESFT.

AB - We describe the case of a 13-year-old girl with multifocal disseminated Ewing sarcoma family of tumor (ESFT) who received a 5/8 human leukocyte antigen-matched haploidentical hematopoietic cell transplantation to generate a graft-versus-tumor effect. The patient had grade 2 acute graft-versus-host disease (GVHD) of the skin and chronic GVHD nausea and abdominal pain that required prednisolone for 17 months, but has been free from ESFT for 3 years 10 months after therapy. The present case suggests a beneficial effect of haploidentical hematopoietic cell transplantation in disseminated ESFT.

KW - Ewing sarcoma

KW - graft-versus-host disease

KW - graft-versus-tumor effect

KW - hematopoietic stem cell transplantation

KW - killer cell immunoglobulin-like receptor

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Haploidentical hematopoietic cell transplantation for disseminated Ewing sarcoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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