Harnessing human dendritic cell subsets to design novel vaccines

Jacques Banchereau, Eynav Klechevsky, Nathalie Schmitt, Rimpei Morita, Karolina Palucka, Hideki Ueno

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Dendritic cells (DCs) orchestrate a repertoire of immune responses that endow resistance to infection and tolerance to self. DC plasticity and subsets are prominent determinants of the quality of elicited immune responses. Different DC subsets display different receptors and surface molecules and express different sets of cytokines/chemokines, all of which lead to distinct immunological outcomes. Recent findings on human DC subsets and their functional specialization have provided insights for the design of novel human vaccines.

Original languageEnglish
Pages (from-to)24-32
Number of pages9
JournalAnnals of the New York Academy of Sciences
Volume1174
DOIs
Publication statusPublished - 2009 Jan 1

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Keywords

  • Dendritic cell
  • Immunology
  • Vaccine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Banchereau, J., Klechevsky, E., Schmitt, N., Morita, R., Palucka, K., & Ueno, H. (2009). Harnessing human dendritic cell subsets to design novel vaccines. Annals of the New York Academy of Sciences, 1174, 24-32. https://doi.org/10.1111/j.1749-6632.2009.04999.x