Haterumaimides A-E, five new dichlorolissoclimide-type diterpenoids from an ascidian, Lissoclinum sp.

Md Jasim Uddin, Susumu Kokubo, Kiyotake Suenaga, Katsuhiro Ueda, Daisuke Uemura

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Five new dichlorolissoclimide-type diterpenoids, haterumaimides A-E, were isolated from an ascidian, Lissoclinum sp., and the absolute stereostructures of haterumaimides A-D and the relative stereostructure of haterumaimide E were determined by spectroscopic and chemical analyses. Haterumaimides A-E inhibited the first cleavage of fertilized sea urchin eggs and exhibited cytotoxicity against P388 cells.

Original languageEnglish
Pages (from-to)1039-1047
Number of pages9
Issue number2
Publication statusPublished - 2001 Feb 1


ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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