Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

M. J. Uddin; S. Kokubo; K. Ueda; K. Suenaga; D. Uemura

doi:10.1021/np010066n

Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

M. J. Uddin, S. Kokubo, K. Ueda, K. Suenaga, D. Uemura

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

Original language	English
Pages (from-to)	1169-1173
Number of pages	5
Journal	Journal of Natural Products
Volume	64
Issue number	9
DOIs	https://doi.org/10.1021/np010066n
Publication status	Published - 2001 Oct 16
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np010066n

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abstract = "Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.",

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AU - Uddin, M. J.

AU - Kokubo, S.

AU - Ueda, K.

AU - Suenaga, K.

AU - Uemura, D.

PY - 2001/10/16

Y1 - 2001/10/16

N2 - Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

AB - Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

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Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

Abstract

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