Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

M. J. Uddin, S. Kokubo, K. Ueda, Kiyotake Suenaga, D. Uemura

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

Original languageEnglish
Pages (from-to)1169-1173
Number of pages5
JournalJournal of Natural Products
Volume64
Issue number9
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Urochordata
Stereochemistry
Sea Urchins
Diterpenes
stereochemistry
Ascidiacea
Cytotoxicity
Echinoidea
Alkaloids
diterpenoids
Eggs
cytotoxicity
alkaloids
cells
dichlorolissoclimide
chlorolissoclimide

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species. / Uddin, M. J.; Kokubo, S.; Ueda, K.; Suenaga, Kiyotake; Uemura, D.

In: Journal of Natural Products, Vol. 64, No. 9, 2001, p. 1169-1173.

Research output: Contribution to journalArticle

Uddin, M. J. ; Kokubo, S. ; Ueda, K. ; Suenaga, Kiyotake ; Uemura, D. / Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species. In: Journal of Natural Products. 2001 ; Vol. 64, No. 9. pp. 1169-1173.
@article{157309bb53d24e4ab261deff461523b2,
title = "Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species",
abstract = "Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.",
author = "Uddin, {M. J.} and S. Kokubo and K. Ueda and Kiyotake Suenaga and D. Uemura",
year = "2001",
doi = "10.1021/np010066n",
language = "English",
volume = "64",
pages = "1169--1173",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "9",

}

TY - JOUR

T1 - Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

AU - Uddin, M. J.

AU - Kokubo, S.

AU - Ueda, K.

AU - Suenaga, Kiyotake

AU - Uemura, D.

PY - 2001

Y1 - 2001

N2 - Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

AB - Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

UR - http://www.scopus.com/inward/record.url?scp=0034795861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034795861&partnerID=8YFLogxK

U2 - 10.1021/np010066n

DO - 10.1021/np010066n

M3 - Article

C2 - 11575950

AN - SCOPUS:0034795861

VL - 64

SP - 1169

EP - 1173

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 9

ER -