Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

M. J. Uddin, S. Kokubo, K. Ueda, K. Suenaga, D. Uemura

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.

Original languageEnglish
Pages (from-to)1169-1173
Number of pages5
JournalJournal of Natural Products
Volume64
Issue number9
DOIs
Publication statusPublished - 2001 Oct 16
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species'. Together they form a unique fingerprint.

Cite this