Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species

M. Jasim Uddin, Susumu Kokubo, Katsuhiro Ueda, Kiyotake Suenaga, Daisuke Uemura

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.

Original languageEnglish
Pages (from-to)1028-1029
Number of pages2
JournalChemistry Letters
Issue number10
Publication statusPublished - 2002 Oct 5
Externally publishedYes

Fingerprint

Diterpenes
Cytotoxicity
Alkaloids

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species. / Uddin, M. Jasim; Kokubo, Susumu; Ueda, Katsuhiro; Suenaga, Kiyotake; Uemura, Daisuke.

In: Chemistry Letters, No. 10, 05.10.2002, p. 1028-1029.

Research output: Contribution to journalArticle

Uddin, M. Jasim ; Kokubo, Susumu ; Ueda, Katsuhiro ; Suenaga, Kiyotake ; Uemura, Daisuke. / Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species. In: Chemistry Letters. 2002 ; No. 10. pp. 1028-1029.
@article{cb70bf2c32c3498fb83f218121b08b08,
title = "Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species",
abstract = "Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.",
author = "Uddin, {M. Jasim} and Susumu Kokubo and Katsuhiro Ueda and Kiyotake Suenaga and Daisuke Uemura",
year = "2002",
month = "10",
day = "5",
language = "English",
pages = "1028--1029",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "Chemical Society of Japan",
number = "10",

}

TY - JOUR

T1 - Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species

AU - Uddin, M. Jasim

AU - Kokubo, Susumu

AU - Ueda, Katsuhiro

AU - Suenaga, Kiyotake

AU - Uemura, Daisuke

PY - 2002/10/5

Y1 - 2002/10/5

N2 - Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.

AB - Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0037027279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037027279&partnerID=8YFLogxK

M3 - Article

SP - 1028

EP - 1029

JO - Chemistry Letters

JF - Chemistry Letters

SN - 0366-7022

IS - 10

ER -