Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species

M. Jasim Uddin; Susumu Kokubo; Katsuhiro Ueda; Kiyotake Suenaga; Daisuke Uemura

doi:10.1246/cl.2002.1028

Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species

M. Jasim Uddin, Susumu Kokubo, Katsuhiro Ueda, Kiyotake Suenaga, Daisuke Uemura

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC₅₀ values of 0.23 ng/mL and 0.45 ng/mL, respectively.

Original language	English
Pages (from-to)	1028-1029
Number of pages	2
Journal	Chemistry Letters
Issue number	10
DOIs	https://doi.org/10.1246/cl.2002.1028
Publication status	Published - 2002 Oct 5
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1246/cl.2002.1028

Fingerprint Dive into the research topics of 'Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species'. Together they form a unique fingerprint.

Cite this

@article{cb70bf2c32c3498fb83f218121b08b08,

title = "Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species",

abstract = "Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.",

author = "Uddin, {M. Jasim} and Susumu Kokubo and Katsuhiro Ueda and Kiyotake Suenaga and Daisuke Uemura",

year = "2002",

month = oct,

day = "5",

doi = "10.1246/cl.2002.1028",

language = "English",

pages = "1028--1029",

journal = "Chemistry Letters",

issn = "0366-7022",

publisher = "Chemical Society of Japan",

number = "10",

}

TY - JOUR

T1 - Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species

AU - Uddin, M. Jasim

AU - Kokubo, Susumu

AU - Ueda, Katsuhiro

AU - Suenaga, Kiyotake

AU - Uemura, Daisuke

PY - 2002/10/5

Y1 - 2002/10/5

N2 - Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.

AB - Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0037027279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037027279&partnerID=8YFLogxK

U2 - 10.1246/cl.2002.1028

DO - 10.1246/cl.2002.1028

M3 - Article

AN - SCOPUS:0037027279

SP - 1028

EP - 1029

JO - Chemistry Letters

JF - Chemistry Letters

SN - 0366-7022

IS - 10

ER -