Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species

M. Jasim Uddin; Susumu Kokubo; Katsuhiro Ueda; Kiyotake Suenaga; Daisuke Uemura

doi:10.1246/cl.2002.1028

Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species

M. Jasim Uddin, Susumu Kokubo, Katsuhiro Ueda, Kiyotake Suenaga, Daisuke Uemura

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC₅₀ values of 0.23 ng/mL and 0.45 ng/mL, respectively.

Original language	English
Pages (from-to)	1028-1029
Number of pages	2
Journal	Chemistry Letters
Issue number	10
DOIs	https://doi.org/10.1246/cl.2002.1028
Publication status	Published - 2002 Oct 5
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2002.1028

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abstract = "Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.",

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AU - Uddin, M. Jasim

AU - Kokubo, Susumu

AU - Ueda, Katsuhiro

AU - Suenaga, Kiyotake

AU - Uemura, Daisuke

PY - 2002/10/5

Y1 - 2002/10/5

N2 - Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.

AB - Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.

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DO - 10.1246/cl.2002.1028

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Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species

Abstract

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