Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species

M. Jasim Uddin, Susumu Kokubo, Katsuhiro Ueda, Kiyotake Suenaga, Daisuke Uemura

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.

Original languageEnglish
Pages (from-to)1028-1029
Number of pages2
JournalChemistry Letters
Issue number10
DOIs
Publication statusPublished - 2002 Oct 5
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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