Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species

M. Jasim Uddin, Susumu Kokubo, Katsuhiro Ueda, Kiyotake Suenaga, Daisuke Uemura

Research output: Contribution to journal › Article

19 Citations (Scopus)

Abstract

Two unique cytotoxic diterpene alkaloids, haterumaimides J and K, were isolated from the ascidian Lissoclinum sp. Their structures were elucidated by an extensive analysis of spectral data. Haterumaimides J and K showed potent cytotoxicity against P388 cells, with IC50 values of 0.23 ng/mL and 0.45 ng/mL, respectively.

Original languageEnglish
Pages (from-to)1028-1029
Number of pages2
JournalChemistry Letters
Issue number10
Publication statusPublished - 2002 Oct 5
Externally publishedYes

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Diterpenes
Cytotoxicity
Alkaloids

ASJC Scopus subject areas

  • Chemistry(all)

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Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species. / Uddin, M. Jasim; Kokubo, Susumu; Ueda, Katsuhiro; Suenaga, Kiyotake; Uemura, Daisuke.

In: Chemistry Letters, No. 10, 05.10.2002, p. 1028-1029.

Research output: Contribution to journal › Article

Uddin, MJ, Kokubo, S, Ueda, K, Suenaga, K & Uemura, D 2002, 'Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species', Chemistry Letters, no. 10, pp. 1028-1029.
Uddin MJ, Kokubo S, Ueda K, Suenaga K, Uemura D. Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species. Chemistry Letters. 2002 Oct 5;(10):1028-1029.
Uddin, M. Jasim ; Kokubo, Susumu ; Ueda, Katsuhiro ; Suenaga, Kiyotake ; Uemura, Daisuke. / Haterumaimides J and K, potent cytotoxic diterpene alkaloids from the ascidian Lissoclinum species. In: Chemistry Letters. 2002 ; No. 10. pp. 1028-1029.
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