HbA1c and the risks for all-cause and cardiovascular mortality in the general Japanese population: NIPPON DATA90

Masaru Sakurai, Shigeyuki Saitoh, Katsuyuki Miura, Hideaki Nakagawa, Hirofumi Ohnishi, Hiroshi Akasaka, Aya Kadota, Yoshikuni Kita, Takehito Hayakawa, Takayoshi Ohkubo, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective - Associations between HbA1c and cardiovascular diseases (CVD) have been reported mainly in Western countries. It is not clear whether HbA1c measurements are useful for assessing CVD mortality risk in East Asian populations. Research Design and Methods - The risk for cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. A total of 7,120 participants (2,962men and 4,158 women; mean age 52.3 years) free of previous CVD were followed for 15 years. Adjusted hazard ratios (HRs) and 95% CIs among categories of HbA1c (<5.0%, 5.0-5.4%, 5.5-5.9%, 6.0-6.4%, and ≥6.5%) for participants without treatment for diabetes and HRs for participants with diabetes were calculated using a Cox proportional hazards model. Results - During the study, there were 1,104 deaths, including 304 from CVD, 61 from coronary heart disease, and 127 from stroke (78 from cerebral infarction, 25 from cerebral hemorrhage, and 24 from unclassified stroke). Relations to HbA1c with all-cause mortality and CVD death were graded and continuous, and multivariate-adjusted HRs for CVD death in participants with HbA1c 6.0-6.4% and ≥6.5%were 2.18 (95% CI 1.22-3.87) and 2.75 (1.43-5.28), respectively, compared with participants with HbA1c <5.0%. Similar associations were observed between HbA1c and death from coronary heart disease and death from cerebral infarction. Conclusions - High HbA1c levels were associated with increased risk for all-cause mortality and death from CVD, coronary heart disease, and cerebral infarction in general East Asian populations, as in Western populations.

Original languageEnglish
Pages (from-to)3759-3765
Number of pages7
JournalDiabetes Care
Volume36
Issue number11
DOIs
Publication statusPublished - 2013 Nov

Fingerprint

Cardiovascular Diseases
Mortality
Cerebral Infarction
Population
Coronary Disease
Stroke
Cerebral Hemorrhage
Proportional Hazards Models
Cause of Death
Research Design

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing
  • Medicine(all)

Cite this

Sakurai, M., Saitoh, S., Miura, K., Nakagawa, H., Ohnishi, H., Akasaka, H., ... Ueshima, H. (2013). HbA1c and the risks for all-cause and cardiovascular mortality in the general Japanese population: NIPPON DATA90. Diabetes Care, 36(11), 3759-3765. https://doi.org/10.2337/dc12-2412

HbA1c and the risks for all-cause and cardiovascular mortality in the general Japanese population : NIPPON DATA90. / Sakurai, Masaru; Saitoh, Shigeyuki; Miura, Katsuyuki; Nakagawa, Hideaki; Ohnishi, Hirofumi; Akasaka, Hiroshi; Kadota, Aya; Kita, Yoshikuni; Hayakawa, Takehito; Ohkubo, Takayoshi; Okayama, Akira; Okamura, Tomonori; Ueshima, Hirotsugu.

In: Diabetes Care, Vol. 36, No. 11, 11.2013, p. 3759-3765.

Research output: Contribution to journalArticle

Sakurai, M, Saitoh, S, Miura, K, Nakagawa, H, Ohnishi, H, Akasaka, H, Kadota, A, Kita, Y, Hayakawa, T, Ohkubo, T, Okayama, A, Okamura, T & Ueshima, H 2013, 'HbA1c and the risks for all-cause and cardiovascular mortality in the general Japanese population: NIPPON DATA90', Diabetes Care, vol. 36, no. 11, pp. 3759-3765. https://doi.org/10.2337/dc12-2412
Sakurai, Masaru ; Saitoh, Shigeyuki ; Miura, Katsuyuki ; Nakagawa, Hideaki ; Ohnishi, Hirofumi ; Akasaka, Hiroshi ; Kadota, Aya ; Kita, Yoshikuni ; Hayakawa, Takehito ; Ohkubo, Takayoshi ; Okayama, Akira ; Okamura, Tomonori ; Ueshima, Hirotsugu. / HbA1c and the risks for all-cause and cardiovascular mortality in the general Japanese population : NIPPON DATA90. In: Diabetes Care. 2013 ; Vol. 36, No. 11. pp. 3759-3765.
@article{502068f566de4793967daddb48d66c6c,
title = "HbA1c and the risks for all-cause and cardiovascular mortality in the general Japanese population: NIPPON DATA90",
abstract = "Objective - Associations between HbA1c and cardiovascular diseases (CVD) have been reported mainly in Western countries. It is not clear whether HbA1c measurements are useful for assessing CVD mortality risk in East Asian populations. Research Design and Methods - The risk for cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. A total of 7,120 participants (2,962men and 4,158 women; mean age 52.3 years) free of previous CVD were followed for 15 years. Adjusted hazard ratios (HRs) and 95{\%} CIs among categories of HbA1c (<5.0{\%}, 5.0-5.4{\%}, 5.5-5.9{\%}, 6.0-6.4{\%}, and ≥6.5{\%}) for participants without treatment for diabetes and HRs for participants with diabetes were calculated using a Cox proportional hazards model. Results - During the study, there were 1,104 deaths, including 304 from CVD, 61 from coronary heart disease, and 127 from stroke (78 from cerebral infarction, 25 from cerebral hemorrhage, and 24 from unclassified stroke). Relations to HbA1c with all-cause mortality and CVD death were graded and continuous, and multivariate-adjusted HRs for CVD death in participants with HbA1c 6.0-6.4{\%} and ≥6.5{\%}were 2.18 (95{\%} CI 1.22-3.87) and 2.75 (1.43-5.28), respectively, compared with participants with HbA1c <5.0{\%}. Similar associations were observed between HbA1c and death from coronary heart disease and death from cerebral infarction. Conclusions - High HbA1c levels were associated with increased risk for all-cause mortality and death from CVD, coronary heart disease, and cerebral infarction in general East Asian populations, as in Western populations.",
author = "Masaru Sakurai and Shigeyuki Saitoh and Katsuyuki Miura and Hideaki Nakagawa and Hirofumi Ohnishi and Hiroshi Akasaka and Aya Kadota and Yoshikuni Kita and Takehito Hayakawa and Takayoshi Ohkubo and Akira Okayama and Tomonori Okamura and Hirotsugu Ueshima",
year = "2013",
month = "11",
doi = "10.2337/dc12-2412",
language = "English",
volume = "36",
pages = "3759--3765",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "11",

}

TY - JOUR

T1 - HbA1c and the risks for all-cause and cardiovascular mortality in the general Japanese population

T2 - NIPPON DATA90

AU - Sakurai, Masaru

AU - Saitoh, Shigeyuki

AU - Miura, Katsuyuki

AU - Nakagawa, Hideaki

AU - Ohnishi, Hirofumi

AU - Akasaka, Hiroshi

AU - Kadota, Aya

AU - Kita, Yoshikuni

AU - Hayakawa, Takehito

AU - Ohkubo, Takayoshi

AU - Okayama, Akira

AU - Okamura, Tomonori

AU - Ueshima, Hirotsugu

PY - 2013/11

Y1 - 2013/11

N2 - Objective - Associations between HbA1c and cardiovascular diseases (CVD) have been reported mainly in Western countries. It is not clear whether HbA1c measurements are useful for assessing CVD mortality risk in East Asian populations. Research Design and Methods - The risk for cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. A total of 7,120 participants (2,962men and 4,158 women; mean age 52.3 years) free of previous CVD were followed for 15 years. Adjusted hazard ratios (HRs) and 95% CIs among categories of HbA1c (<5.0%, 5.0-5.4%, 5.5-5.9%, 6.0-6.4%, and ≥6.5%) for participants without treatment for diabetes and HRs for participants with diabetes were calculated using a Cox proportional hazards model. Results - During the study, there were 1,104 deaths, including 304 from CVD, 61 from coronary heart disease, and 127 from stroke (78 from cerebral infarction, 25 from cerebral hemorrhage, and 24 from unclassified stroke). Relations to HbA1c with all-cause mortality and CVD death were graded and continuous, and multivariate-adjusted HRs for CVD death in participants with HbA1c 6.0-6.4% and ≥6.5%were 2.18 (95% CI 1.22-3.87) and 2.75 (1.43-5.28), respectively, compared with participants with HbA1c <5.0%. Similar associations were observed between HbA1c and death from coronary heart disease and death from cerebral infarction. Conclusions - High HbA1c levels were associated with increased risk for all-cause mortality and death from CVD, coronary heart disease, and cerebral infarction in general East Asian populations, as in Western populations.

AB - Objective - Associations between HbA1c and cardiovascular diseases (CVD) have been reported mainly in Western countries. It is not clear whether HbA1c measurements are useful for assessing CVD mortality risk in East Asian populations. Research Design and Methods - The risk for cardiovascular death was evaluated in a large cohort of participants selected randomly from the overall Japanese population. A total of 7,120 participants (2,962men and 4,158 women; mean age 52.3 years) free of previous CVD were followed for 15 years. Adjusted hazard ratios (HRs) and 95% CIs among categories of HbA1c (<5.0%, 5.0-5.4%, 5.5-5.9%, 6.0-6.4%, and ≥6.5%) for participants without treatment for diabetes and HRs for participants with diabetes were calculated using a Cox proportional hazards model. Results - During the study, there were 1,104 deaths, including 304 from CVD, 61 from coronary heart disease, and 127 from stroke (78 from cerebral infarction, 25 from cerebral hemorrhage, and 24 from unclassified stroke). Relations to HbA1c with all-cause mortality and CVD death were graded and continuous, and multivariate-adjusted HRs for CVD death in participants with HbA1c 6.0-6.4% and ≥6.5%were 2.18 (95% CI 1.22-3.87) and 2.75 (1.43-5.28), respectively, compared with participants with HbA1c <5.0%. Similar associations were observed between HbA1c and death from coronary heart disease and death from cerebral infarction. Conclusions - High HbA1c levels were associated with increased risk for all-cause mortality and death from CVD, coronary heart disease, and cerebral infarction in general East Asian populations, as in Western populations.

UR - http://www.scopus.com/inward/record.url?scp=84891869989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891869989&partnerID=8YFLogxK

U2 - 10.2337/dc12-2412

DO - 10.2337/dc12-2412

M3 - Article

C2 - 23877989

AN - SCOPUS:84891869989

VL - 36

SP - 3759

EP - 3765

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 11

ER -