Abstract
Purpose : To investigate the diagnostic accuracy of head and neck cancer, lymph node metastasis, and local tumor recurrence, by FDG-PET compared with CT and MRI, and to validate the results with the histopathological data. Patients and Methods : Forty one patients with head and neck cancer were enrolled. Our patients presented for primary staging of head and neck cancer (n =23) or monitoring after therapy (n = 18). The three imaging modalities (FDG-PET, MRI and CT) were compared. Results : Overall 82 head and neck regions were analyzed for detection of malignancy (for primary tumors ; n = 23, for lymph node metastasis ; n = 41, for local tumor recurrence after therapy ; n = 18). The overall sensitivity and specificity were ; CT 88.9% and 89.2% (95% CI ; 80.2-94.9%, r = 0.7791, P < 0.0001), MRI 88.9% and 91.9% (95% CI ; 81.9-95.8%, r = 0.8049, P < 0.0001), and FDG-PET 97.78% and 86.49% (95% CI ; 84-96.9%, r = 0.8551, P < 0.0001). Only FDG-PET by its unique advantage as a whole-body examination could detect distant metastases in 4/41 (9.8 %) patients, all outside the head and neck region (liver, lung, paraortic lymph nodes, and bone metastases), and synchronous breast cancer in 1/41 (2.4 %) patient. Conclusion : Compared with CT and MRI, FDG-PET was found to have the highest sensitivity with lower specificity than CT and MRI. Moreover, the whole-body FDG-PET imaging proves useful tool for detection of distant metastasis and synchronous tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 179-192 |
| Number of pages | 14 |
| Journal | Dokkyo Journal of Medical Sciences |
| Volume | 34 |
| Issue number | 3 |
| Publication status | Published - 2007 Oct |
| Externally published | Yes |
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Keywords
- CT
- FDG-PET
- Head and neck cancer
- Lymph node metastasis
- MRI
ASJC Scopus subject areas
- Medicine(all)
Cite this
Head and Neck Cancer : Comparative Evaluation by CT, MRI and FDG-PET. / Zytoon, Ashraf Anas; Murakami, Koji.
In: Dokkyo Journal of Medical Sciences, Vol. 34, No. 3, 10.2007, p. 179-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Head and Neck Cancer
T2 - Comparative Evaluation by CT, MRI and FDG-PET
AU - Zytoon, Ashraf Anas
AU - Murakami, Koji
PY - 2007/10
Y1 - 2007/10
N2 - Purpose : To investigate the diagnostic accuracy of head and neck cancer, lymph node metastasis, and local tumor recurrence, by FDG-PET compared with CT and MRI, and to validate the results with the histopathological data. Patients and Methods : Forty one patients with head and neck cancer were enrolled. Our patients presented for primary staging of head and neck cancer (n =23) or monitoring after therapy (n = 18). The three imaging modalities (FDG-PET, MRI and CT) were compared. Results : Overall 82 head and neck regions were analyzed for detection of malignancy (for primary tumors ; n = 23, for lymph node metastasis ; n = 41, for local tumor recurrence after therapy ; n = 18). The overall sensitivity and specificity were ; CT 88.9% and 89.2% (95% CI ; 80.2-94.9%, r = 0.7791, P < 0.0001), MRI 88.9% and 91.9% (95% CI ; 81.9-95.8%, r = 0.8049, P < 0.0001), and FDG-PET 97.78% and 86.49% (95% CI ; 84-96.9%, r = 0.8551, P < 0.0001). Only FDG-PET by its unique advantage as a whole-body examination could detect distant metastases in 4/41 (9.8 %) patients, all outside the head and neck region (liver, lung, paraortic lymph nodes, and bone metastases), and synchronous breast cancer in 1/41 (2.4 %) patient. Conclusion : Compared with CT and MRI, FDG-PET was found to have the highest sensitivity with lower specificity than CT and MRI. Moreover, the whole-body FDG-PET imaging proves useful tool for detection of distant metastasis and synchronous tumors.
AB - Purpose : To investigate the diagnostic accuracy of head and neck cancer, lymph node metastasis, and local tumor recurrence, by FDG-PET compared with CT and MRI, and to validate the results with the histopathological data. Patients and Methods : Forty one patients with head and neck cancer were enrolled. Our patients presented for primary staging of head and neck cancer (n =23) or monitoring after therapy (n = 18). The three imaging modalities (FDG-PET, MRI and CT) were compared. Results : Overall 82 head and neck regions were analyzed for detection of malignancy (for primary tumors ; n = 23, for lymph node metastasis ; n = 41, for local tumor recurrence after therapy ; n = 18). The overall sensitivity and specificity were ; CT 88.9% and 89.2% (95% CI ; 80.2-94.9%, r = 0.7791, P < 0.0001), MRI 88.9% and 91.9% (95% CI ; 81.9-95.8%, r = 0.8049, P < 0.0001), and FDG-PET 97.78% and 86.49% (95% CI ; 84-96.9%, r = 0.8551, P < 0.0001). Only FDG-PET by its unique advantage as a whole-body examination could detect distant metastases in 4/41 (9.8 %) patients, all outside the head and neck region (liver, lung, paraortic lymph nodes, and bone metastases), and synchronous breast cancer in 1/41 (2.4 %) patient. Conclusion : Compared with CT and MRI, FDG-PET was found to have the highest sensitivity with lower specificity than CT and MRI. Moreover, the whole-body FDG-PET imaging proves useful tool for detection of distant metastasis and synchronous tumors.
KW - CT
KW - FDG-PET
KW - Head and neck cancer
KW - Lymph node metastasis
KW - MRI
UR - http://www.scopus.com/inward/record.url?scp=38749153218&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38749153218&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:38749153218
VL - 34
SP - 179
EP - 192
JO - Dokkyo Journal of Medical Sciences
JF - Dokkyo Journal of Medical Sciences
SN - 0385-5023
IS - 3
ER -