Abstract
We describe the case of a 55-year-old man who underwent four cycles of cabazitaxel therapy for castration- resistant prostate cancer (CRPC). After the fourth cycle of cabazitaxel, the patient experienced severe headaches. Brain gadolinium (Gd) contrast-enhanced magnetic resonance imaging (MRI) revealed multiple brain metastases. A few days later, the patient suffered impaired consciousness that progressed rapidly. The patient was treated for the symptoms of increased intracranial pressure and underwent whole-brain radiation. One month later, the patient’s consciousness level and headache had improved. Although brain metastases of prostate cancer are rare, the possibility of brain metastases should be considered for prostate cancer patients, especially when a CRPC patient complains of headache. Additionally, even if major conditions such as cerebral hemorrhage are excluded by the use of non-contrast enhanced computed tomography, brain Gd contrast-enhanced MRI should be performed in consideration of the possibility of brain metastases of prostate cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 65-71 |
| Number of pages | 7 |
| Journal | Keio Journal of Medicine |
| Volume | 66 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2017 Jan 1 |
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Keywords
- Brain metastases
- Cabazitaxel
- Gadolinium contrast-enhanced MRI
- Headache
- Prostate cancer
ASJC Scopus subject areas
- Medicine(all)
Cite this
Headache caused by brain metastases of castration-resistant prostate cancer during cabazitaxel therapy. / Watanabe, Keitaro; Kosaka, Takeo; Hongo, Hiroshi; Tamaki, Satoshi; Oya, Mototsugu.
In: Keio Journal of Medicine, Vol. 66, No. 4, 01.01.2017, p. 65-71.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Headache caused by brain metastases of castration-resistant prostate cancer during cabazitaxel therapy
AU - Watanabe, Keitaro
AU - Kosaka, Takeo
AU - Hongo, Hiroshi
AU - Tamaki, Satoshi
AU - Oya, Mototsugu
PY - 2017/1/1
Y1 - 2017/1/1
N2 - We describe the case of a 55-year-old man who underwent four cycles of cabazitaxel therapy for castration- resistant prostate cancer (CRPC). After the fourth cycle of cabazitaxel, the patient experienced severe headaches. Brain gadolinium (Gd) contrast-enhanced magnetic resonance imaging (MRI) revealed multiple brain metastases. A few days later, the patient suffered impaired consciousness that progressed rapidly. The patient was treated for the symptoms of increased intracranial pressure and underwent whole-brain radiation. One month later, the patient’s consciousness level and headache had improved. Although brain metastases of prostate cancer are rare, the possibility of brain metastases should be considered for prostate cancer patients, especially when a CRPC patient complains of headache. Additionally, even if major conditions such as cerebral hemorrhage are excluded by the use of non-contrast enhanced computed tomography, brain Gd contrast-enhanced MRI should be performed in consideration of the possibility of brain metastases of prostate cancer.
AB - We describe the case of a 55-year-old man who underwent four cycles of cabazitaxel therapy for castration- resistant prostate cancer (CRPC). After the fourth cycle of cabazitaxel, the patient experienced severe headaches. Brain gadolinium (Gd) contrast-enhanced magnetic resonance imaging (MRI) revealed multiple brain metastases. A few days later, the patient suffered impaired consciousness that progressed rapidly. The patient was treated for the symptoms of increased intracranial pressure and underwent whole-brain radiation. One month later, the patient’s consciousness level and headache had improved. Although brain metastases of prostate cancer are rare, the possibility of brain metastases should be considered for prostate cancer patients, especially when a CRPC patient complains of headache. Additionally, even if major conditions such as cerebral hemorrhage are excluded by the use of non-contrast enhanced computed tomography, brain Gd contrast-enhanced MRI should be performed in consideration of the possibility of brain metastases of prostate cancer.
KW - Brain metastases
KW - Cabazitaxel
KW - Gadolinium contrast-enhanced MRI
KW - Headache
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=85039793252&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039793252&partnerID=8YFLogxK
U2 - 10.2302/kjm.2016-0014-CR
DO - 10.2302/kjm.2016-0014-CR
M3 - Article
C2 - 28392539
AN - SCOPUS:85039793252
VL - 66
SP - 65
EP - 71
JO - Keio Journal of Medicine
JF - Keio Journal of Medicine
SN - 0022-9717
IS - 4
ER -