Health-related QOL of elderly patients with pulmonary M. avium complex disease in a university hospital

T. Asakura, Makoto Ishii, K. Ishii, Shoji Suzuki, H. Namkoong, S. Okamori, Hirofumi Kamata, K. Yagi, Y. Funatsu, Tomoko Betsuyaku, Naoki Hasegawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Little is known about the clinical characteristics and health-related quality of life (HQOL) of elderly patients with pulmonary Mycobacterium avium complex (pMAC) disease. Objectives : To evaluate HQOL using the 36-Item Short-Form Health Survey and St George's Respiratory Questionnaire (SGRQ) and to investigate the predictors of HQOL changes among elderly patients with pMAC disease. Methods : This prospective cohort registry was conducted at Keio University Hospital, Tokyo, Japan, between May 2012 and July 2015 and included 84 patients with pMAC disease aged ≥75 years who had completed the HQOL questionnaire and 48 patients with pMAC disease who had been followed up and completed the HQOL questionnaire in cross-sectional and longitudinal analyses, respectively. Results : In cross-sectional analyses, elderly patients with pMAC disease had significantly lower rolephysical, general health, vitality, social functioning, role-emotional and role/social component scores than the general Japanese elderly population. Analysis of covariance revealed that patients with cavitary lesions had significantly worse physical functioning and SGRQ scores (P < 0.05). Longitudinal analysis showed that under-treatment, short duration of disease and positive sputum smear at baseline were predictors of worse HQOL at 12 months. Conclusions : Elderly patients with pMAC disease have reduced HQOL. Further large studies on HQOL are required to refine the use of this parameter in the treatment of these patients.

Original languageEnglish
Pages (from-to)695-703
Number of pages9
JournalInternational Journal of Tuberculosis and Lung Disease
Volume22
Issue number6
DOIs
Publication statusPublished - 2018 Jun 1

Fingerprint

Mycobacterium avium Complex
Quality of Life
Lung
Health
Cross-Sectional Studies
Tokyo
Health Surveys
Sputum
Registries
Japan
Surveys and Questionnaires
Therapeutics
Population

Keywords

  • 36-Item Short-Form Health Survey (SF-36)
  • Cavitary lesions
  • Non-tuberculous mycobacteria (NTM)
  • St George's Respiratory Questionnaire (SGRQ)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Health-related QOL of elderly patients with pulmonary M. avium complex disease in a university hospital. / Asakura, T.; Ishii, Makoto; Ishii, K.; Suzuki, Shoji; Namkoong, H.; Okamori, S.; Kamata, Hirofumi; Yagi, K.; Funatsu, Y.; Betsuyaku, Tomoko; Hasegawa, Naoki.

In: International Journal of Tuberculosis and Lung Disease, Vol. 22, No. 6, 01.06.2018, p. 695-703.

Research output: Contribution to journalArticle

@article{c66ecd2d60454e74bae262cd46ff8f82,
title = "Health-related QOL of elderly patients with pulmonary M. avium complex disease in a university hospital",
abstract = "Background: Little is known about the clinical characteristics and health-related quality of life (HQOL) of elderly patients with pulmonary Mycobacterium avium complex (pMAC) disease. Objectives : To evaluate HQOL using the 36-Item Short-Form Health Survey and St George's Respiratory Questionnaire (SGRQ) and to investigate the predictors of HQOL changes among elderly patients with pMAC disease. Methods : This prospective cohort registry was conducted at Keio University Hospital, Tokyo, Japan, between May 2012 and July 2015 and included 84 patients with pMAC disease aged ≥75 years who had completed the HQOL questionnaire and 48 patients with pMAC disease who had been followed up and completed the HQOL questionnaire in cross-sectional and longitudinal analyses, respectively. Results : In cross-sectional analyses, elderly patients with pMAC disease had significantly lower rolephysical, general health, vitality, social functioning, role-emotional and role/social component scores than the general Japanese elderly population. Analysis of covariance revealed that patients with cavitary lesions had significantly worse physical functioning and SGRQ scores (P < 0.05). Longitudinal analysis showed that under-treatment, short duration of disease and positive sputum smear at baseline were predictors of worse HQOL at 12 months. Conclusions : Elderly patients with pMAC disease have reduced HQOL. Further large studies on HQOL are required to refine the use of this parameter in the treatment of these patients.",
keywords = "36-Item Short-Form Health Survey (SF-36), Cavitary lesions, Non-tuberculous mycobacteria (NTM), St George's Respiratory Questionnaire (SGRQ)",
author = "T. Asakura and Makoto Ishii and K. Ishii and Shoji Suzuki and H. Namkoong and S. Okamori and Hirofumi Kamata and K. Yagi and Y. Funatsu and Tomoko Betsuyaku and Naoki Hasegawa",
year = "2018",
month = "6",
day = "1",
doi = "10.5588/ijtld.17.0433",
language = "English",
volume = "22",
pages = "695--703",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "6",

}

TY - JOUR

T1 - Health-related QOL of elderly patients with pulmonary M. avium complex disease in a university hospital

AU - Asakura, T.

AU - Ishii, Makoto

AU - Ishii, K.

AU - Suzuki, Shoji

AU - Namkoong, H.

AU - Okamori, S.

AU - Kamata, Hirofumi

AU - Yagi, K.

AU - Funatsu, Y.

AU - Betsuyaku, Tomoko

AU - Hasegawa, Naoki

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Background: Little is known about the clinical characteristics and health-related quality of life (HQOL) of elderly patients with pulmonary Mycobacterium avium complex (pMAC) disease. Objectives : To evaluate HQOL using the 36-Item Short-Form Health Survey and St George's Respiratory Questionnaire (SGRQ) and to investigate the predictors of HQOL changes among elderly patients with pMAC disease. Methods : This prospective cohort registry was conducted at Keio University Hospital, Tokyo, Japan, between May 2012 and July 2015 and included 84 patients with pMAC disease aged ≥75 years who had completed the HQOL questionnaire and 48 patients with pMAC disease who had been followed up and completed the HQOL questionnaire in cross-sectional and longitudinal analyses, respectively. Results : In cross-sectional analyses, elderly patients with pMAC disease had significantly lower rolephysical, general health, vitality, social functioning, role-emotional and role/social component scores than the general Japanese elderly population. Analysis of covariance revealed that patients with cavitary lesions had significantly worse physical functioning and SGRQ scores (P < 0.05). Longitudinal analysis showed that under-treatment, short duration of disease and positive sputum smear at baseline were predictors of worse HQOL at 12 months. Conclusions : Elderly patients with pMAC disease have reduced HQOL. Further large studies on HQOL are required to refine the use of this parameter in the treatment of these patients.

AB - Background: Little is known about the clinical characteristics and health-related quality of life (HQOL) of elderly patients with pulmonary Mycobacterium avium complex (pMAC) disease. Objectives : To evaluate HQOL using the 36-Item Short-Form Health Survey and St George's Respiratory Questionnaire (SGRQ) and to investigate the predictors of HQOL changes among elderly patients with pMAC disease. Methods : This prospective cohort registry was conducted at Keio University Hospital, Tokyo, Japan, between May 2012 and July 2015 and included 84 patients with pMAC disease aged ≥75 years who had completed the HQOL questionnaire and 48 patients with pMAC disease who had been followed up and completed the HQOL questionnaire in cross-sectional and longitudinal analyses, respectively. Results : In cross-sectional analyses, elderly patients with pMAC disease had significantly lower rolephysical, general health, vitality, social functioning, role-emotional and role/social component scores than the general Japanese elderly population. Analysis of covariance revealed that patients with cavitary lesions had significantly worse physical functioning and SGRQ scores (P < 0.05). Longitudinal analysis showed that under-treatment, short duration of disease and positive sputum smear at baseline were predictors of worse HQOL at 12 months. Conclusions : Elderly patients with pMAC disease have reduced HQOL. Further large studies on HQOL are required to refine the use of this parameter in the treatment of these patients.

KW - 36-Item Short-Form Health Survey (SF-36)

KW - Cavitary lesions

KW - Non-tuberculous mycobacteria (NTM)

KW - St George's Respiratory Questionnaire (SGRQ)

UR - http://www.scopus.com/inward/record.url?scp=85046977522&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046977522&partnerID=8YFLogxK

U2 - 10.5588/ijtld.17.0433

DO - 10.5588/ijtld.17.0433

M3 - Article

C2 - 29862956

AN - SCOPUS:85046977522

VL - 22

SP - 695

EP - 703

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 6

ER -