Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum

Midori A. Arai; Ryuta Akamine; Samir K. Sadhu; Firoj Ahmed; Masami Ishibashi

doi:10.1007/s11418-015-0922-8

Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum

Midori A. Arai, Ryuta Akamine, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The inhibition of the hedgehog (Hh) signaling pathway has emerged as an attractive anti-cancer strategy. As part of our continuing search for natural inhibitors of the Hh/GLI1 signaling pathway, we isolated three alkaloids (1-3) from Crinum asiaticum. Compounds 1 and 3 showed potent Hh/GLI1-mediated transcriptional inhibitory activity and exhibited cytotoxicity against human pancreatic (PANC1) and prostate (DU145) cancer cells. Our data revealed that compounds 1 and 3 clearly inhibited the Hh signaling pathway by down-regulating the expression of GLI-related proteins (PTCH and BCL2) in DU145 cells.

Original language	English
Pages (from-to)	538-542
Number of pages	5
Journal	Journal of Natural Medicines
Volume	69
Issue number	4
DOIs	https://doi.org/10.1007/s11418-015-0922-8
Publication status	Published - 2015 Oct 11
Externally published	Yes

Keywords

Crinum asiaticum
Hedgehog/GLI1 signaling pathway inhibitor

ASJC Scopus subject areas

Molecular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11418-015-0922-8

Cite this

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abstract = "The inhibition of the hedgehog (Hh) signaling pathway has emerged as an attractive anti-cancer strategy. As part of our continuing search for natural inhibitors of the Hh/GLI1 signaling pathway, we isolated three alkaloids (1-3) from Crinum asiaticum. Compounds 1 and 3 showed potent Hh/GLI1-mediated transcriptional inhibitory activity and exhibited cytotoxicity against human pancreatic (PANC1) and prostate (DU145) cancer cells. Our data revealed that compounds 1 and 3 clearly inhibited the Hh signaling pathway by down-regulating the expression of GLI-related proteins (PTCH and BCL2) in DU145 cells.",

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AU - Arai, Midori A.

AU - Akamine, Ryuta

AU - Sadhu, Samir K.

AU - Ahmed, Firoj

AU - Ishibashi, Masami

PY - 2015/10/11

Y1 - 2015/10/11

N2 - The inhibition of the hedgehog (Hh) signaling pathway has emerged as an attractive anti-cancer strategy. As part of our continuing search for natural inhibitors of the Hh/GLI1 signaling pathway, we isolated three alkaloids (1-3) from Crinum asiaticum. Compounds 1 and 3 showed potent Hh/GLI1-mediated transcriptional inhibitory activity and exhibited cytotoxicity against human pancreatic (PANC1) and prostate (DU145) cancer cells. Our data revealed that compounds 1 and 3 clearly inhibited the Hh signaling pathway by down-regulating the expression of GLI-related proteins (PTCH and BCL2) in DU145 cells.

AB - The inhibition of the hedgehog (Hh) signaling pathway has emerged as an attractive anti-cancer strategy. As part of our continuing search for natural inhibitors of the Hh/GLI1 signaling pathway, we isolated three alkaloids (1-3) from Crinum asiaticum. Compounds 1 and 3 showed potent Hh/GLI1-mediated transcriptional inhibitory activity and exhibited cytotoxicity against human pancreatic (PANC1) and prostate (DU145) cancer cells. Our data revealed that compounds 1 and 3 clearly inhibited the Hh signaling pathway by down-regulating the expression of GLI-related proteins (PTCH and BCL2) in DU145 cells.

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Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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