Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum

Midori A. Arai, Ryuta Akamine, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The inhibition of the hedgehog (Hh) signaling pathway has emerged as an attractive anti-cancer strategy. As part of our continuing search for natural inhibitors of the Hh/GLI1 signaling pathway, we isolated three alkaloids (1-3) from Crinum asiaticum. Compounds 1 and 3 showed potent Hh/GLI1-mediated transcriptional inhibitory activity and exhibited cytotoxicity against human pancreatic (PANC1) and prostate (DU145) cancer cells. Our data revealed that compounds 1 and 3 clearly inhibited the Hh signaling pathway by down-regulating the expression of GLI-related proteins (PTCH and BCL2) in DU145 cells.

Original languageEnglish
Pages (from-to)538-542
Number of pages5
JournalJournal of Natural Medicines
Volume69
Issue number4
DOIs
Publication statusPublished - 2015 Oct 11
Externally publishedYes

Keywords

  • Crinum asiaticum
  • Hedgehog/GLI1 signaling pathway inhibitor

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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