Helicobacter cinaedi bacteremia with cellulitis after ABO-incompatible living-donor liver transplantation

Case report

Kohei Mishima, Hideaki Obara, Kayoko Sugita, Masahiro Shinoda, Minoru Kitago, Yuta Abe, Taizo Hibi, Hiroshi Yagi, Kentaro Matsubara, Takehiko Mori, Yaoko Takano, Hiroshi Fujiwara, Osamu Itano, Naoki Hasegawa, Satoshi Iwata, Yuukou Kitagawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Helicobacter cinaedi (H. cinaedi), a Gram-negative spiral-shaped bacterium, is an enterohepatic non-Helicobacter pylori Helicobacter species. We report the first case of H. cinaedi bacteremia with cellulitis after liver transplantation. A 48-year-old male, who had been a dog breeder for 15 years, underwent ABO-incompatible living-donor liver transplantation for hepatitis C virus-induced decompensated cirrhosis using an anti-hepatitis B core antibody-positive graft. The patient was preoperatively administered rituximab and underwent plasma exchange twice to overcome blood type incompatibility. After discharge, he had been doing well with immunosuppression therapy comprising cyclosporine, mycophenolate mofetil, and steroid according to the ABO-incompatible protocol of our institution. However, 7 mo after transplantation, he was admitted to our hospital with a diagnosis of recurrent cellulitis on the left lower extremity, and H. cinaedi was detected by both blood culture and polymerase chain reaction analysis. Antibiotics improved his symptoms, and he was discharged at day 30 after admission. Clinicians should be more aware of H. cinaedi in immunocompromised patients, such as ABO-incompatible transplant recipients.

Original languageEnglish
Pages (from-to)7911-7915
Number of pages5
JournalWorld Journal of Gastroenterology
Volume21
Issue number25
DOIs
Publication statusPublished - 2015 Jul 1

Fingerprint

Helicobacter
Cellulitis
Living Donors
Bacteremia
Liver Transplantation
Mycophenolic Acid
Hepatitis B Antibodies
Plasma Exchange
Immunocompromised Host
Helicobacter pylori
Hepacivirus
Immunosuppression
Cyclosporine
Lower Extremity
Fibrosis
Transplantation
Steroids
Dogs
Anti-Bacterial Agents
Bacteria

Keywords

  • Aboincompatible
  • Bacteremia
  • Cellulitis
  • HBc-Ab-positive donor
  • Helicobacter cinaedi
  • Hepatitis C
  • Liver transplantation
  • Living-donor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Helicobacter cinaedi bacteremia with cellulitis after ABO-incompatible living-donor liver transplantation : Case report. / Mishima, Kohei; Obara, Hideaki; Sugita, Kayoko; Shinoda, Masahiro; Kitago, Minoru; Abe, Yuta; Hibi, Taizo; Yagi, Hiroshi; Matsubara, Kentaro; Mori, Takehiko; Takano, Yaoko; Fujiwara, Hiroshi; Itano, Osamu; Hasegawa, Naoki; Iwata, Satoshi; Kitagawa, Yuukou.

In: World Journal of Gastroenterology, Vol. 21, No. 25, 01.07.2015, p. 7911-7915.

Research output: Contribution to journalArticle

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