TY - JOUR
T1 - Helicobacter pylori eradication prevents secondary gastric cancer in patients with mild-to-moderate atrophic gastritis
AU - Kato, Minoru
AU - Hayashi, Yoshito
AU - Nishida, Tsutomu
AU - Oshita, Masahide
AU - Nakanishi, Fumihiko
AU - Yamaguchi, Shinjiro
AU - Kitamura, Shinji
AU - Nishihara, Akihiro
AU - Akasaka, Tomofumi
AU - Ogiyama, Hideharu
AU - Nakahara, Masanori
AU - Yamada, Takuya
AU - Kishida, Osamu
AU - Yamamoto, Masashi
AU - Shimayoshi, Akinori
AU - Tsujii, Yoshiki
AU - Kato, Motohiko
AU - Shinzaki, Shinichiro
AU - Iijima, Hideki
AU - Takehara, Tetsuo
N1 - Funding Information:
The authors wish to express their gratitude to Drs Ryotaro Uema, Hirotsugu Saiki, Keiichi Kimura, Takanori Inoue, Akihiko Sakatani, Shunsuke Yoshii (Osaka University), Dai Nakamatsu, Masami Inada (Toyonaka Municipal Hospital), Satoshi Egawa (Osaka Police Hospital), Eiji Masuda (Osaka Minami Medical Center), Hideki Hagiwara (Kansai Rosai Hospital), Akira Kaneko (Minoh City Hospital), Shunsuke Yamamoto, Eiji Mita (Osaka National Hospital), Shusaku Tsutsui (Itami City Hospital), Yasuharu Imai (Ikeda Municipal Hospital), Naoki Hiramatsu (Osaka Rosai Hospital), and Akira Yamada (Sumitomo Hospital) for significant assistance with study preparation. We also appreciate the statistical advice from Eisuke Hida (Department of Biostatics and Data Science, Osaka University Graduate School of Medicine). We would like to thank Editage (www.editage.com) for English language editing.
Publisher Copyright:
© 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
PY - 2021/8
Y1 - 2021/8
N2 - Background and Aim: Whether Helicobacter pylori eradication prevents metachronous recurrence after endoscopic resection (ER) of early gastric cancer remains controversial. This multicenter retrospective study aimed to evaluate the long-term (> 5 years) effects of H. pylori eradication by stratifying patients' baseline degrees of atrophic gastritis. Methods: A total of 483 H. pylori-positive patients who had undergone ER for early gastric cancer were divided into two groups—(i) those having undergone successful H. pylori eradication within 1 year after ER (eradicated group, n = 294) and (ii) those with failed or not attempted H. pylori eradication (non-eradicated group, n = 189). The cumulative incidences of metachronous gastric cancer between the two groups were compared for all patients, for patients with mild-to-moderate atrophic gastritis (n = 182), and for patients with severe atrophic gastritis (n = 301). Results: During a median follow-up of 5.2 years (range 1.1–14.8), metachronous cancer developed in 52 (17.7%) patients in the eradicated group and in 35 (18.5%) patients in the non-eradicated group (P = 0.11, log–rank test). In patients with mild-to-moderate atrophic gastritis (111 and 71 in the eradicated and non-eradicated groups, respectively), the cumulative incidence of metachronous cancer was significantly lower in the eradicated group than that in the non-eradicated group (P = 0.03, log–rank test). However, no significant intergroup difference was observed in patients with severe atrophic gastritis (P = 0.69, log–rank test). Conclusions: Helicobacter pylori eradication had a preventive effect on the development of metachronous gastric cancer in patients with mild-to-moderate atrophic gastritis.
AB - Background and Aim: Whether Helicobacter pylori eradication prevents metachronous recurrence after endoscopic resection (ER) of early gastric cancer remains controversial. This multicenter retrospective study aimed to evaluate the long-term (> 5 years) effects of H. pylori eradication by stratifying patients' baseline degrees of atrophic gastritis. Methods: A total of 483 H. pylori-positive patients who had undergone ER for early gastric cancer were divided into two groups—(i) those having undergone successful H. pylori eradication within 1 year after ER (eradicated group, n = 294) and (ii) those with failed or not attempted H. pylori eradication (non-eradicated group, n = 189). The cumulative incidences of metachronous gastric cancer between the two groups were compared for all patients, for patients with mild-to-moderate atrophic gastritis (n = 182), and for patients with severe atrophic gastritis (n = 301). Results: During a median follow-up of 5.2 years (range 1.1–14.8), metachronous cancer developed in 52 (17.7%) patients in the eradicated group and in 35 (18.5%) patients in the non-eradicated group (P = 0.11, log–rank test). In patients with mild-to-moderate atrophic gastritis (111 and 71 in the eradicated and non-eradicated groups, respectively), the cumulative incidence of metachronous cancer was significantly lower in the eradicated group than that in the non-eradicated group (P = 0.03, log–rank test). However, no significant intergroup difference was observed in patients with severe atrophic gastritis (P = 0.69, log–rank test). Conclusions: Helicobacter pylori eradication had a preventive effect on the development of metachronous gastric cancer in patients with mild-to-moderate atrophic gastritis.
KW - Helicobacter pylori
KW - atrophic gastritis
KW - endoscopic resection
KW - gastric cancer
KW - metachronous cancer
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UR - http://www.scopus.com/inward/citedby.url?scp=85100051075&partnerID=8YFLogxK
U2 - 10.1111/jgh.15396
DO - 10.1111/jgh.15396
M3 - Article
C2 - 33403702
AN - SCOPUS:85100051075
VL - 36
SP - 2083
EP - 2090
JO - Journal of Gastroenterology and Hepatology (Australia)
JF - Journal of Gastroenterology and Hepatology (Australia)
SN - 0815-9319
IS - 8
ER -
