Helicobacter pylori infection in subjects negative for high titer serum antibody

Osamu Toyoshima, Toshihiro Nishizawa, Masahide Arita, Yosuke Kataoka, Kosuke Sakitani, Shuntaro Yoshida, Hiroharu Yamashita, Keisuke Hata, Hidenobu Watanabe, Hidekazu Suzuki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

AIM To investigate the clinicopathological features of the patients testing negative for high titer serum antiHelicobacter pylori (H. pylori) antibody. METHODS The antibody titers were measured using antigens derived from Japanese individuals. 13C-urea breath test-positive individuals were defined as having H. pylori infection. We investigated the demographic characteristics, laboratory data, endoscopic findings including Kyoto classifcation of gastritis, and histology in negative-high titer patients without H. pylori eradication therapy. Kyoto classification consisted of scores for gastric atrophy, intestinal metaplasia, enlarged folds, nodularity, and redness. RESULTS Of the 136 subjects enrolled, 23 (17%) had H. pylori infection. Kyoto classification had an excellent area under the receiver operating characteristics curve (0.886, 95% confdence interval: 0.803-0.968, P = 3.7 × 10-20) for predicting H. pylori infection with a cutoff value of 2. Further, Kyoto classification, H. pylori density, and neutrophil activity had high accuracies (89.7%, 96.3%, and 94.1%, respectively). Kyoto classifcation was independent of the demographic and laboratory parameters in multivariate analysis. CONCLUSION Endoscopic Kyoto classification of gastritis is a useful predictor of H. pylori infection in negative-high titer antibody patients.

Original languageEnglish
Pages (from-to)1419-1428
Number of pages10
JournalWorld Journal of Gastroenterology
Volume24
Issue number13
DOIs
Publication statusPublished - 2018 Apr 7

Fingerprint

Helicobacter Infections
Helicobacter pylori
Antibodies
Serum
Gastritis
Demography
Breath Tests
Pylorus
Metaplasia
ROC Curve
Atrophy
Urea
Stomach
Histology
Neutrophils
Multivariate Analysis
Antigens

Keywords

  • Antibody
  • Endoscopy
  • Gastritis
  • Helicobacter pylori
  • Kyoto classifcation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Toyoshima, O., Nishizawa, T., Arita, M., Kataoka, Y., Sakitani, K., Yoshida, S., ... Suzuki, H. (2018). Helicobacter pylori infection in subjects negative for high titer serum antibody. World Journal of Gastroenterology, 24(13), 1419-1428. https://doi.org/10.3748/wjg.v24.i13.1419

Helicobacter pylori infection in subjects negative for high titer serum antibody. / Toyoshima, Osamu; Nishizawa, Toshihiro; Arita, Masahide; Kataoka, Yosuke; Sakitani, Kosuke; Yoshida, Shuntaro; Yamashita, Hiroharu; Hata, Keisuke; Watanabe, Hidenobu; Suzuki, Hidekazu.

In: World Journal of Gastroenterology, Vol. 24, No. 13, 07.04.2018, p. 1419-1428.

Research output: Contribution to journalArticle

Toyoshima, O, Nishizawa, T, Arita, M, Kataoka, Y, Sakitani, K, Yoshida, S, Yamashita, H, Hata, K, Watanabe, H & Suzuki, H 2018, 'Helicobacter pylori infection in subjects negative for high titer serum antibody', World Journal of Gastroenterology, vol. 24, no. 13, pp. 1419-1428. https://doi.org/10.3748/wjg.v24.i13.1419
Toyoshima O, Nishizawa T, Arita M, Kataoka Y, Sakitani K, Yoshida S et al. Helicobacter pylori infection in subjects negative for high titer serum antibody. World Journal of Gastroenterology. 2018 Apr 7;24(13):1419-1428. https://doi.org/10.3748/wjg.v24.i13.1419
Toyoshima, Osamu ; Nishizawa, Toshihiro ; Arita, Masahide ; Kataoka, Yosuke ; Sakitani, Kosuke ; Yoshida, Shuntaro ; Yamashita, Hiroharu ; Hata, Keisuke ; Watanabe, Hidenobu ; Suzuki, Hidekazu. / Helicobacter pylori infection in subjects negative for high titer serum antibody. In: World Journal of Gastroenterology. 2018 ; Vol. 24, No. 13. pp. 1419-1428.
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abstract = "AIM To investigate the clinicopathological features of the patients testing negative for high titer serum antiHelicobacter pylori (H. pylori) antibody. METHODS The antibody titers were measured using antigens derived from Japanese individuals. 13C-urea breath test-positive individuals were defined as having H. pylori infection. We investigated the demographic characteristics, laboratory data, endoscopic findings including Kyoto classifcation of gastritis, and histology in negative-high titer patients without H. pylori eradication therapy. Kyoto classification consisted of scores for gastric atrophy, intestinal metaplasia, enlarged folds, nodularity, and redness. RESULTS Of the 136 subjects enrolled, 23 (17{\%}) had H. pylori infection. Kyoto classification had an excellent area under the receiver operating characteristics curve (0.886, 95{\%} confdence interval: 0.803-0.968, P = 3.7 × 10-20) for predicting H. pylori infection with a cutoff value of 2. Further, Kyoto classification, H. pylori density, and neutrophil activity had high accuracies (89.7{\%}, 96.3{\%}, and 94.1{\%}, respectively). Kyoto classifcation was independent of the demographic and laboratory parameters in multivariate analysis. CONCLUSION Endoscopic Kyoto classification of gastritis is a useful predictor of H. pylori infection in negative-high titer antibody patients.",
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