Helicobacter pylori: Present status and future prospects in Japan

Hidekazu Suzuki, Toshifumi Hibi, Barry James Marshall

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

The discovery of Helicobacter pylori has already changed the natural history of peptic ulcer disease, with most patients being cured at their first presentation. Similarly, the incidence of gastric cancer and other diseases related to H. pylori are likely to be greatly reduced in the near future. Isolation of the spiral intragastric bacterium H. pylori totally reversed the false dogma that the stomach was sterile, and it taught us that chronic infectious disease can still exist in modern society. Helicobacter pylori's unique location, persistence, and evasion of the immune system offer important insights into the pathophysiology of the gut. Also, the fact that it was overlooked for so long encourages us to think "outside the box" when investigating other diseases with obscure etiologies. We should consider such provocative scientific ideas as bridges to the future disease control.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalJournal of Gastroenterology
Volume42
Issue number1
DOIs
Publication statusPublished - 2007 Jan

Fingerprint

Helicobacter pylori
Japan
Peptic Ulcer
Stomach Neoplasms
Communicable Diseases
Immune System
Stomach
Chronic Disease
Bacteria
Incidence

Keywords

  • Gastric cancer
  • Gastritis
  • H. pylori diagnosis
  • H. pylori eradication
  • Peptic ulcer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Helicobacter pylori : Present status and future prospects in Japan. / Suzuki, Hidekazu; Hibi, Toshifumi; Marshall, Barry James.

In: Journal of Gastroenterology, Vol. 42, No. 1, 01.2007, p. 1-15.

Research output: Contribution to journalArticle

Suzuki, Hidekazu ; Hibi, Toshifumi ; Marshall, Barry James. / Helicobacter pylori : Present status and future prospects in Japan. In: Journal of Gastroenterology. 2007 ; Vol. 42, No. 1. pp. 1-15.
@article{dcc2695b889d488ba51959d7ee1a16dc,
title = "Helicobacter pylori: Present status and future prospects in Japan",
abstract = "The discovery of Helicobacter pylori has already changed the natural history of peptic ulcer disease, with most patients being cured at their first presentation. Similarly, the incidence of gastric cancer and other diseases related to H. pylori are likely to be greatly reduced in the near future. Isolation of the spiral intragastric bacterium H. pylori totally reversed the false dogma that the stomach was sterile, and it taught us that chronic infectious disease can still exist in modern society. Helicobacter pylori's unique location, persistence, and evasion of the immune system offer important insights into the pathophysiology of the gut. Also, the fact that it was overlooked for so long encourages us to think {"}outside the box{"} when investigating other diseases with obscure etiologies. We should consider such provocative scientific ideas as bridges to the future disease control.",
keywords = "Gastric cancer, Gastritis, H. pylori diagnosis, H. pylori eradication, Peptic ulcer",
author = "Hidekazu Suzuki and Toshifumi Hibi and Marshall, {Barry James}",
year = "2007",
month = "1",
doi = "10.1007/s00535-006-1990-z",
language = "English",
volume = "42",
pages = "1--15",
journal = "Journal of Gastroenterology",
issn = "0944-1174",
publisher = "Springer Japan",
number = "1",

}

TY - JOUR

T1 - Helicobacter pylori

T2 - Present status and future prospects in Japan

AU - Suzuki, Hidekazu

AU - Hibi, Toshifumi

AU - Marshall, Barry James

PY - 2007/1

Y1 - 2007/1

N2 - The discovery of Helicobacter pylori has already changed the natural history of peptic ulcer disease, with most patients being cured at their first presentation. Similarly, the incidence of gastric cancer and other diseases related to H. pylori are likely to be greatly reduced in the near future. Isolation of the spiral intragastric bacterium H. pylori totally reversed the false dogma that the stomach was sterile, and it taught us that chronic infectious disease can still exist in modern society. Helicobacter pylori's unique location, persistence, and evasion of the immune system offer important insights into the pathophysiology of the gut. Also, the fact that it was overlooked for so long encourages us to think "outside the box" when investigating other diseases with obscure etiologies. We should consider such provocative scientific ideas as bridges to the future disease control.

AB - The discovery of Helicobacter pylori has already changed the natural history of peptic ulcer disease, with most patients being cured at their first presentation. Similarly, the incidence of gastric cancer and other diseases related to H. pylori are likely to be greatly reduced in the near future. Isolation of the spiral intragastric bacterium H. pylori totally reversed the false dogma that the stomach was sterile, and it taught us that chronic infectious disease can still exist in modern society. Helicobacter pylori's unique location, persistence, and evasion of the immune system offer important insights into the pathophysiology of the gut. Also, the fact that it was overlooked for so long encourages us to think "outside the box" when investigating other diseases with obscure etiologies. We should consider such provocative scientific ideas as bridges to the future disease control.

KW - Gastric cancer

KW - Gastritis

KW - H. pylori diagnosis

KW - H. pylori eradication

KW - Peptic ulcer

UR - http://www.scopus.com/inward/record.url?scp=33847660516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847660516&partnerID=8YFLogxK

U2 - 10.1007/s00535-006-1990-z

DO - 10.1007/s00535-006-1990-z

M3 - Article

C2 - 17322988

AN - SCOPUS:33847660516

VL - 42

SP - 1

EP - 15

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

SN - 0944-1174

IS - 1

ER -