Helminth infection promotes colonization resistance via type 2 immunity

Deepshika Ramanan, Rowann Bowcutt, Soo Ching Lee, Mei San Tang, Zachary D. Kurtz, Yi Ding, Kenya Honda, William C. Gause, Martin J. Blaser, Richard A. Bonneau, Yvonne A L Lim, P'ng Loke, Ken Cadwell

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Increasing incidence of inflammatory bowel diseases, such as Crohn's disease, in developed nations is associated with changes to the microbial environment, such as decreased prevalence of helminth colonization and alterations to the gut microbiota.We find that helminth infection protects mice deficient in the Crohn's disease susceptibility gene Nod2 from intestinal abnormalities by inhibiting colonization by an inflammatory Bacteroides species. Resistance to Bacteroides colonization was dependent on type 2 immunity, which promoted the establishment of a protective microbiota enriched in Clostridiales. Additionally, we show that individuals from helminth-endemic regions harbor a similar protective microbiota and that deworming treatment reduced levels of Clostridiales and increased Bacteroidales. These results support a model of the hygiene hypothesis in which certain individuals are genetically susceptible to the consequences of a changing microbial environment.

Original languageEnglish
Pages (from-to)608-612
Number of pages5
JournalScience
Volume352
Issue number6285
DOIs
Publication statusPublished - 2016 Apr 29
Externally publishedYes

Fingerprint

Helminths
Immunity
Bacteroides
Microbiota
Crohn Disease
Hygiene Hypothesis
Infection
Disease Susceptibility
Inflammatory Bowel Diseases
Developed Countries
Incidence
Genes
Clostridiales

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Ramanan, D., Bowcutt, R., Lee, S. C., Tang, M. S., Kurtz, Z. D., Ding, Y., ... Cadwell, K. (2016). Helminth infection promotes colonization resistance via type 2 immunity. Science, 352(6285), 608-612. https://doi.org/10.1126/science.aaf3229

Helminth infection promotes colonization resistance via type 2 immunity. / Ramanan, Deepshika; Bowcutt, Rowann; Lee, Soo Ching; Tang, Mei San; Kurtz, Zachary D.; Ding, Yi; Honda, Kenya; Gause, William C.; Blaser, Martin J.; Bonneau, Richard A.; Lim, Yvonne A L; Loke, P'ng; Cadwell, Ken.

In: Science, Vol. 352, No. 6285, 29.04.2016, p. 608-612.

Research output: Contribution to journalArticle

Ramanan, D, Bowcutt, R, Lee, SC, Tang, MS, Kurtz, ZD, Ding, Y, Honda, K, Gause, WC, Blaser, MJ, Bonneau, RA, Lim, YAL, Loke, P & Cadwell, K 2016, 'Helminth infection promotes colonization resistance via type 2 immunity', Science, vol. 352, no. 6285, pp. 608-612. https://doi.org/10.1126/science.aaf3229
Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y et al. Helminth infection promotes colonization resistance via type 2 immunity. Science. 2016 Apr 29;352(6285):608-612. https://doi.org/10.1126/science.aaf3229
Ramanan, Deepshika ; Bowcutt, Rowann ; Lee, Soo Ching ; Tang, Mei San ; Kurtz, Zachary D. ; Ding, Yi ; Honda, Kenya ; Gause, William C. ; Blaser, Martin J. ; Bonneau, Richard A. ; Lim, Yvonne A L ; Loke, P'ng ; Cadwell, Ken. / Helminth infection promotes colonization resistance via type 2 immunity. In: Science. 2016 ; Vol. 352, No. 6285. pp. 608-612.
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