TY - JOUR
T1 - Helminthosporic acid functions as an agonist for gibberellin receptor
AU - Miyazaki, Sho
AU - Jiang, Kai
AU - Kobayashi, Masatomo
AU - Asami, Tadao
AU - Nakajima, Masatoshi
N1 - Funding Information:
This work was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI [grant number 24380060], [grant number 15H04492 (to MN)], [grant number 16K18693 (to SM)]; the agricultural chemical research foundation (to SM); and the Wada Kunko-kai research foundation (to MN).
Publisher Copyright:
© 2017 Japan Society for Bioscience, Biotechnology, and Agrochemistry.
PY - 2017
Y1 - 2017
N2 - Helminthosporol was isolated from a fungus, Helminthosporium sativum, as a natural plant growth regulator in 1963. It showed gibberellin-like bioactivity that stimulated the growth of the second leaf sheath of rice. After studying the structure–activity relationship between the compound and some synthesized analogs, it was found that helminthosporic acid (H-acid) has higher gibberellin-like activity and chemical stability than helminthosporol. In this study, we showed that (1) H-acid displays gibberellin-like activities not only in rice but also in Arabidopsis, (2) it regulates the expression of gibberellin-related genes, (3) it induces DELLA degradation through binding with a gibberellin receptor (GID1), and (4) it forms the GID1-(H-acid)-DELLA complex to transduce the gibberellin signal in the same manner as gibberellin. This work shows that the H-acid mode of action acts as an agonist for gibberellin receptor.
AB - Helminthosporol was isolated from a fungus, Helminthosporium sativum, as a natural plant growth regulator in 1963. It showed gibberellin-like bioactivity that stimulated the growth of the second leaf sheath of rice. After studying the structure–activity relationship between the compound and some synthesized analogs, it was found that helminthosporic acid (H-acid) has higher gibberellin-like activity and chemical stability than helminthosporol. In this study, we showed that (1) H-acid displays gibberellin-like activities not only in rice but also in Arabidopsis, (2) it regulates the expression of gibberellin-related genes, (3) it induces DELLA degradation through binding with a gibberellin receptor (GID1), and (4) it forms the GID1-(H-acid)-DELLA complex to transduce the gibberellin signal in the same manner as gibberellin. This work shows that the H-acid mode of action acts as an agonist for gibberellin receptor.
KW - GA-like
KW - Gibberellin
KW - Helminthosporic acid
KW - Helminthosporol
KW - Natural product
UR - http://www.scopus.com/inward/record.url?scp=85034573751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034573751&partnerID=8YFLogxK
U2 - 10.1080/09168451.2017.1381018
DO - 10.1080/09168451.2017.1381018
M3 - Article
C2 - 29017401
AN - SCOPUS:85034573751
SN - 0916-8451
VL - 81
SP - 2152
EP - 2159
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 11
ER -