Helminthosporic acid functions as an agonist for gibberellin receptor

Sho Miyazaki, Kai Jiang, Masatomo Kobayashi, Tadao Asami, Masatoshi Nakajima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Helminthosporol was isolated from a fungus, Helminthosporium sativum, as a natural plant growth regulator in 1963. It showed gibberellin-like bioactivity that stimulated the growth of the second leaf sheath of rice. After studying the structure–activity relationship between the compound and some synthesized analogs, it was found that helminthosporic acid (H-acid) has higher gibberellin-like activity and chemical stability than helminthosporol. In this study, we showed that (1) H-acid displays gibberellin-like activities not only in rice but also in Arabidopsis, (2) it regulates the expression of gibberellin-related genes, (3) it induces DELLA degradation through binding with a gibberellin receptor (GID1), and (4) it forms the GID1-(H-acid)-DELLA complex to transduce the gibberellin signal in the same manner as gibberellin. This work shows that the H-acid mode of action acts as an agonist for gibberellin receptor.

Original languageEnglish
Pages (from-to)2152-2159
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume81
Issue number11
DOIs
Publication statusPublished - 2017 Jan 1
Externally publishedYes

Fingerprint

Gibberellins
Helminthosporium
Plant Growth Regulators
helminthosporic acid
Chemical stability
Bioactivity
Fungi
Arabidopsis
Genes
Display devices
Degradation

Keywords

  • GA-like
  • Gibberellin
  • Helminthosporic acid
  • Helminthosporol
  • Natural product

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Helminthosporic acid functions as an agonist for gibberellin receptor. / Miyazaki, Sho; Jiang, Kai; Kobayashi, Masatomo; Asami, Tadao; Nakajima, Masatoshi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 81, No. 11, 01.01.2017, p. 2152-2159.

Research output: Contribution to journalArticle

Miyazaki, Sho ; Jiang, Kai ; Kobayashi, Masatomo ; Asami, Tadao ; Nakajima, Masatoshi. / Helminthosporic acid functions as an agonist for gibberellin receptor. In: Bioscience, Biotechnology and Biochemistry. 2017 ; Vol. 81, No. 11. pp. 2152-2159.
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