Helper T cell diversity and plasticity

Shingo Nakayamada, Hayato Takahashi, Yuka Kanno, John J. O'Shea

Research output: Contribution to journalReview articlepeer-review

234 Citations (Scopus)

Abstract

CD4 + helper T cells play crucial roles for host defense and immune-mediated disease by their ability to differentiate into specialized subsets. These subsets attain restricted patterns of cytokine secretion and specific expression of master transcription factors in response to microbial pathogens. Classically, the various helper CD4 + T cell subsets have been viewed as terminally differentiated lineages with limited flexibility. However, following the recognition of new subsets, there is increased recognition of plasticity. In this review, we highlight recent advances that pertain to this topic and the mechanisms that contribute to helper CD4 + T cell differentiation and plasticity.

Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalCurrent Opinion in Immunology
Volume24
Issue number3
DOIs
Publication statusPublished - 2012 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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