Helper t cell plasticity: Impact of extrinsic and intrinsic signals on transcriptomes and epigenomes

Michael Bonelli; Han Yu Shih; Kiyoshi Hirahara; Kentner Singelton; Arian Laurence; Amanda Poholek; Tim Hand; Yohei Mikami; Golnaz Vahedi; Yuka Kanno; John J. O’Shea

doi:10.1007/82_2014_371

Helper t cell plasticity: Impact of extrinsic and intrinsic signals on transcriptomes and epigenomes

Michael Bonelli, Han Yu Shih, Kiyoshi Hirahara, Kentner Singelton, Arian Laurence, Amanda Poholek, Tim Hand, Yohei Mikami, Golnaz Vahedi, Yuka Kanno, John J. O’Shea

Department of Internal Medicine (Gastroenterology and Hepatology)

Research output: Contribution to journal › Article

30 Citations (Scopus)

Abstract

CD4+ helper T cells are crucial for autoimmune and infectious diseases; however, the recognition of the many, diverse fates available continues unabated. Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review, we will discuss the major factors that impact helper T cell fate choice, ranging from cytokines and the microbiome to metabolic control and epigenetic regulation. We will also discuss the technological advances along with the attendant challenges presented by “big data,” which allow the understanding of these processes on comprehensive scales.

Original language	English
Pages (from-to)	279-326
Number of pages	48
Journal	Current topics in microbiology and immunology
Volume	381
DOIs	https://doi.org/10.1007/82_2014_371
Publication status	Published - 2015

ASJC Scopus subject areas

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)

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Bonelli, M., Shih, H. Y., Hirahara, K., Singelton, K., Laurence, A., Poholek, A., Hand, T., Mikami, Y., Vahedi, G., Kanno, Y., & O’Shea, J. J. (2015). Helper t cell plasticity: Impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Current topics in microbiology and immunology, 381, 279-326. https://doi.org/10.1007/82_2014_371

Helper t cell plasticity : Impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. / Bonelli, Michael; Shih, Han Yu; Hirahara, Kiyoshi; Singelton, Kentner; Laurence, Arian; Poholek, Amanda; Hand, Tim; Mikami, Yohei; Vahedi, Golnaz; Kanno, Yuka; O’Shea, John J.

In: Current topics in microbiology and immunology, Vol. 381, 2015, p. 279-326.

Research output: Contribution to journal › Article

Bonelli, Michael ; Shih, Han Yu ; Hirahara, Kiyoshi ; Singelton, Kentner ; Laurence, Arian ; Poholek, Amanda ; Hand, Tim ; Mikami, Yohei ; Vahedi, Golnaz ; Kanno, Yuka ; O’Shea, John J. / Helper t cell plasticity : Impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. In: Current topics in microbiology and immunology. 2015 ; Vol. 381. pp. 279-326.

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