TY - JOUR
T1 - Helper t cell plasticity
T2 - Impact of extrinsic and intrinsic signals on transcriptomes and epigenomes
AU - Bonelli, Michael
AU - Shih, Han Yu
AU - Hirahara, Kiyoshi
AU - Singelton, Kentner
AU - Laurence, Arian
AU - Poholek, Amanda
AU - Hand, Tim
AU - Mikami, Yohei
AU - Vahedi, Golnaz
AU - Kanno, Yuka
AU - O’Shea, John J.
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2014.
PY - 2015
Y1 - 2015
N2 - CD4+ helper T cells are crucial for autoimmune and infectious diseases; however, the recognition of the many, diverse fates available continues unabated. Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review, we will discuss the major factors that impact helper T cell fate choice, ranging from cytokines and the microbiome to metabolic control and epigenetic regulation. We will also discuss the technological advances along with the attendant challenges presented by “big data,” which allow the understanding of these processes on comprehensive scales.
AB - CD4+ helper T cells are crucial for autoimmune and infectious diseases; however, the recognition of the many, diverse fates available continues unabated. Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review, we will discuss the major factors that impact helper T cell fate choice, ranging from cytokines and the microbiome to metabolic control and epigenetic regulation. We will also discuss the technological advances along with the attendant challenges presented by “big data,” which allow the understanding of these processes on comprehensive scales.
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U2 - 10.1007/82_2014_371
DO - 10.1007/82_2014_371
M3 - Article
C2 - 24831346
AN - SCOPUS:84918563756
VL - 381
SP - 279
EP - 326
JO - Ergebnisse der Hygiene, Bakteriologie, Immunitätsforschung und experimentellen Therapie
JF - Ergebnisse der Hygiene, Bakteriologie, Immunitätsforschung und experimentellen Therapie
SN - 0070-217X
ER -