Helper t cell plasticity: Impact of extrinsic and intrinsic signals on transcriptomes and epigenomes

Michael Bonelli, Han Yu Shih, Kiyoshi Hirahara, Kentner Singelton, Arian Laurence, Amanda Poholek, Tim Hand, Yohei Mikami, Golnaz Vahedi, Yuka Kanno, John J. O’Shea

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

CD4+ helper T cells are crucial for autoimmune and infectious diseases; however, the recognition of the many, diverse fates available continues unabated. Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review, we will discuss the major factors that impact helper T cell fate choice, ranging from cytokines and the microbiome to metabolic control and epigenetic regulation. We will also discuss the technological advances along with the attendant challenges presented by “big data,” which allow the understanding of these processes on comprehensive scales.

Original languageEnglish
Pages (from-to)279-326
Number of pages48
JournalCurrent topics in microbiology and immunology
Volume381
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

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    Bonelli, M., Shih, H. Y., Hirahara, K., Singelton, K., Laurence, A., Poholek, A., Hand, T., Mikami, Y., Vahedi, G., Kanno, Y., & O’Shea, J. J. (2015). Helper t cell plasticity: Impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Current topics in microbiology and immunology, 381, 279-326. https://doi.org/10.1007/82_2014_371