Hemangioendothelial sarcoma in brown adipose tissue of mouse induced by carcinogenic heterocyclic amine, Glu-P-1

Michiie Sakamoto, S. Takayama, Y. Hosoda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

2-Amino-6-methyldipyrido[1,2-a:3',2'-d]limidazole, a potent bacterial mutagen from glutamic acid pyrolysate, when give to male CDF1 mice at a concentration of 0.05% in the diet induced blood vessel tumors characterized histopathologically. These hemangioendothelial sarcomas showed positive alkaline phosphatase activity histochemically and Weibel-Palade bodies ultrastructurally. Neoplasms were predilective for brown adipose tissue and foci of atypical cells, not peliosis-like lesions, appear to be an early stage in tumor development.

Original languageEnglish
Pages (from-to)754-758
Number of pages5
JournalToxicologic Pathology
Volume17
Issue number4 II
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole
Brown Adipose Tissue
Sarcoma
Amines
Tumors
Weibel-Palade Bodies
Tissue
Vascular Tissue Neoplasms
Purpura
Blood vessels
Mutagens
Nutrition
Alkaline Phosphatase
Glutamic Acid
Neoplasms
Diet

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Hemangioendothelial sarcoma in brown adipose tissue of mouse induced by carcinogenic heterocyclic amine, Glu-P-1. / Sakamoto, Michiie; Takayama, S.; Hosoda, Y.

In: Toxicologic Pathology, Vol. 17, No. 4 II, 1989, p. 754-758.

Research output: Contribution to journalArticle

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