Hematopoiesis and angiogenesis

Toshio Suda

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Hematopoiesis is closely linked with angiogenesis, because they interact with each other and have common ancestors: hemangioblasts or hematogenic endothelial cells. The relationship is reasonable, because vascular and hematopoietic systems must develop together in order to establish the body's oxygen-delivery system during organogenesis. Hematopoietic stem cells have been shown to originate from the para-aortic splanchnopleural mesoderm region or aorta-gonads-mesonephros at successive stages. We discuss the molecular events in the differentiation of hematopoietic cells and endothelial cells. Transcription factors SCL/tal-1 and AML1; tyrosine kinase receptors Flk-1,Tie-2, Eph, and the sialomucins; CD34; thrombomucin; and AA4 play important biological roles in these lineages.

Original languageEnglish
Pages (from-to)99-107
Number of pages9
JournalInternational journal of hematology
Volume71
Issue number2
Publication statusPublished - 2000 Dec 1

Keywords

  • Ephs
  • Hemangioblasts
  • Hematopoietic stem cells
  • TIE2
  • Vascular endothelial cells

ASJC Scopus subject areas

  • Hematology

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