Abstract
Hematopoiesis is closely linked with angiogenesis, because they interact with each other and have common ancestors: hemangioblasts or hematogenic endothelial cells. The relationship is reasonable, because vascular and hematopoietic systems must develop together in order to establish the body's oxygen-delivery system during organogenesis. Hematopoietic stem cells have been shown to originate from the para-aortic splanchnopleural mesoderm region or aorta-gonads-mesonephros at successive stages. We discuss the molecular events in the differentiation of hematopoietic cells and endothelial cells. Transcription factors SCL/tal-1 and AML1; tyrosine kinase receptors Flk-1,Tie-2, Eph, and the sialomucins; CD34; thrombomucin; and AA4 play important biological roles in these lineages.
| Original language | English |
|---|---|
| Pages (from-to) | 99-107 |
| Number of pages | 9 |
| Journal | International journal of hematology |
| Volume | 71 |
| Issue number | 2 |
| Publication status | Published - 2000 |
| Externally published | Yes |
Keywords
- Ephs
- Hemangioblasts
- Hematopoietic stem cells
- TIE2
- Vascular endothelial cells
ASJC Scopus subject areas
- Hematology