Hematopoietic cells regulate the angiogenic switch during tumorigenesis

Rika Okamoto, Masaya Ueno, Yoshihiro Yamada, Naoko Takahashi, Hideto Sano, Toshio Suda, Nobuyuki Takakura

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Hematopoietic cells (HCs) promote blood vessel formation by producing various proangiogenic cytokines and chemokines and matrix metalloproteinases. We injected mouse colon26 colon cancer cells or human PC3 prostate adenocarcinoma cells into mice and studied the localization of HCs during tumor development. HCs were distributed in the inner tumor mass in all of the tumor tissues examined; however, the localization of HCs in the tumor tissue differed depending on the tumor cell type. In the case of colon26 tumors, as the tumor grew, many mature HCs migrated into the tumor mass before fine capillary formation was observed. On the other hand, although very few HCs migrated into PC3 tumor tissue, c-Kit+ hematopoietic stem/progenitor cells accumulated around the edge of the tumor. Bone marrow suppression induced by injection of anti-c-Kit neutralizing antibody suppressed tumor angiogenesis by different mechanisms according to the tumor cell type: bone marrow suppression inhibited the initiation of sprouting angiogenesis in colon26 tumors, while it suppressed an increase in the caliber of newly developed blood vessels at the tumor edge in PC3 tumors. Our findings suggest that HCs are involved in tumor angiogenesis and regulate the angiogenic switch during tumorigenesis.

Original languageEnglish
Pages (from-to)2757-2763
Number of pages7
JournalBlood
Volume105
Issue number7
DOIs
Publication statusPublished - 2005 Apr 1

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Tumors
Carcinogenesis
Switches
Neoplasms
Cells
Blood vessels
Hematopoietic Stem Cells
Tissue
Bone
Vascular Tissue Neoplasms
Neutralizing Antibodies
Matrix Metalloproteinases
Chemokines
Bone Marrow Cells
Stem cells
Colonic Neoplasms
Blood Vessels
Prostate
Adenocarcinoma
Bone Marrow

ASJC Scopus subject areas

  • Hematology

Cite this

Okamoto, R., Ueno, M., Yamada, Y., Takahashi, N., Sano, H., Suda, T., & Takakura, N. (2005). Hematopoietic cells regulate the angiogenic switch during tumorigenesis. Blood, 105(7), 2757-2763. https://doi.org/10.1182/blood-2004-08-3317

Hematopoietic cells regulate the angiogenic switch during tumorigenesis. / Okamoto, Rika; Ueno, Masaya; Yamada, Yoshihiro; Takahashi, Naoko; Sano, Hideto; Suda, Toshio; Takakura, Nobuyuki.

In: Blood, Vol. 105, No. 7, 01.04.2005, p. 2757-2763.

Research output: Contribution to journalArticle

Okamoto, R, Ueno, M, Yamada, Y, Takahashi, N, Sano, H, Suda, T & Takakura, N 2005, 'Hematopoietic cells regulate the angiogenic switch during tumorigenesis', Blood, vol. 105, no. 7, pp. 2757-2763. https://doi.org/10.1182/blood-2004-08-3317
Okamoto R, Ueno M, Yamada Y, Takahashi N, Sano H, Suda T et al. Hematopoietic cells regulate the angiogenic switch during tumorigenesis. Blood. 2005 Apr 1;105(7):2757-2763. https://doi.org/10.1182/blood-2004-08-3317
Okamoto, Rika ; Ueno, Masaya ; Yamada, Yoshihiro ; Takahashi, Naoko ; Sano, Hideto ; Suda, Toshio ; Takakura, Nobuyuki. / Hematopoietic cells regulate the angiogenic switch during tumorigenesis. In: Blood. 2005 ; Vol. 105, No. 7. pp. 2757-2763.
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