Hematopoietic stem cell transplantation for therapy-related myelodysplastic syndrome and acute leukemia: A single-center analysis of 47 patients

Hiroki Yokoyama, Shin Ichiro Mori, Yukio Kobayashi, Saiko Kurosawa, Bungo Saito, Shigeo Fuji, Dai Maruyama, Teruhisa Azuma, Sung Won Kim, Takashi Watanabe, Ryuji Tanosaki, Kensei Tobinai, Yoichi Takaue, Takahiro Fukuda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The prognosis of therapy-related myelodysplastic syndrome and acute leukemia (t-MDS/AL) remains poor. We retrospectively analyzed the data of 47 patients (31 AL and 16 MDS) who were treated at our institute. Thirty-three patients received disease-adapted chemotherapy, with a response rate of 73%, while 14 received no interventions due to an indolent course, such as MDS. The median follow-up of surviving patients was 1.9 years (range 0.1-10.5) after the diagnosis of t-MDS/AL, and the estimated 3-year overall survival (OS) for all patients was 55%. Twenty-seven patients underwent allogeneic hematopoietic stem cell transplantation (HCT), and the 3-year non-relapse mortality was 17%. Twenty patients did not undergo HCT due to various reasons including advanced age or comorbidities. The 3-year OS was better in patients who received HCT than in those who did not (71 vs. 31%; p = 0.018). A multivariate analysis revealed that HCT was associated with a better OS. Although this study has several limitations, including a potential selection bias due to the retrospective nature of the analysis and a small number of patients, the results show that modern HCT may be useful for inducing long-term survival in a fraction of patients suffering from t-MDS/AL. The present findings warrant future prospective studies.

Original languageEnglish
Pages (from-to)334-341
Number of pages8
JournalInternational journal of hematology
Volume92
Issue number2
DOIs
Publication statusPublished - 2010 Sep

Keywords

  • Acute leukemia
  • Therapy-related myelodysplastic syndrome
  • Transplantation

ASJC Scopus subject areas

  • Hematology

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